SELECTIVE REDUCTION OF [I-125] APAMIN BINDING-SITES IN ALZHEIMER HIPPOCAMPUS - A QUANTITATIVE AUTORADIOGRAPHIC STUDY

被引：27

作者：

IKEDA, M ^{[1
]}

DEWAR, D ^{[1
]}

MCCULLOCH, J ^{[1
]}

机构：

[1] UNIV GLASGOW,HUGH FRASER NEUROSCI LABS,GLASGOW G61 1QH,SCOTLAND

来源：

BRAIN RESEARCH | 1991年 / 567卷 / 01期

基金：

英国惠康基金;

关键词：

APAMIN; CA2+-DEPENDENT K+ CHANNEL; HIPPOCAMPUS; ALZHEIMERS DISEASE; AUTORADIOGRAPHY;

D O I：

10.1016/0006-8993(91)91434-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

[I-125]Apamin binding sites were examined using quantitative autoradiography in the hippocampus of 9 patients with Alzheimer's disease and 8 age-matched controls. Within the hippocampal formation from control subjects, [I-125]apamin binding sites were highly concentrated in the subiculum and CA1. In Alzheimer's disease there was a marked and discrete loss of [I-125]apamin binding sites in the subiculum (control = 1.10 +/- 0.10 pmol/g; Alzheimer = 0.71 +/- 0.09 pmol/g) and CA1 (control = 1.41 +/- 0.09 pmol/g; Alzheimer = 0.85 +/- 0.11 pmol/g; values are mean +/- S.E.M.). This reduction of [I-125]apamin binding sites in the subiculum correlated with cell density but not neuritic plaque density. These results indicate that an anatomically discrete loss of Ca2+-dependent K+ channels within the hippocampal formation occurs in Alzheimer's disease.

引用

页码：51 / 56

页数：6

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