AN ECO-FRIENDLY SYNTHESIS OF N-ALKYL-2-AMINO BENZIMIDAZOLE

被引:0
作者
Rao, Sadhu Srinivas [1 ]
机构
[1] Vidya Jyothi Inst Technol Autonomous, Dept Chem, Hyderabad 500075, Andhra Pradesh, India
来源
HETEROCYCLIC LETTERS | 2016年 / 6卷 / 02期
关键词
Green synthesis; benzimidazole; grinding; microwave; 2-amino benzimidazole;
D O I
暂无
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A green approach for the synthesis of N-alkyl-2-aminobenzimidazoles 2 (R-1 = CH3, C2H5, CH2Ph) under, different conditions has been developed from 2-aminobenzimidazole 1 by reaction with an alkylating agent by physical grinding or by using green solvent like PEG-600 or by using micro-wave irradiation technique.
引用
收藏
页码:181 / 184
页数:4
相关论文
共 13 条
[1]   Mechanosynthesis of the Metallodrug Bismuth Subsalicylate from Bi2O3 and Structure of Bismuth Salicylate without Auxiliary Organic Ligands [J].
Andre, Vania ;
Hardeman, Andrew ;
Halasz, Ivan ;
Stein, Robin S. ;
Jackson, Graham J. ;
Reid, David G. ;
Duer, Melinda J. ;
Curfs, Caroline ;
Teresa Duarte, M. ;
Friscic, Tomislav .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2011, 50 (34) :7858-7861
[2]  
Anelia T, 2007, BIOORGAN MED CHEM, V15, P6291
[3]  
Atkinson M B J, 2008, CHEM COMMUN, V14, P10570
[4]   SYNTHESES OF HETEROCYCLIC FUSED THIAZOLE ACETIC-ACIDS .2. [J].
BELL, SC ;
WEI, PHL .
JOURNAL OF MEDICINAL CHEMISTRY, 1976, 19 (04) :524-530
[5]  
Dubey P K, 2005, INDIAN J CHEM, V44, P417
[6]   REACTION OF 2-(ALKYLSULFINYL)-BENZIMIDAZOLE, 2-(ARYLSULFINYL)-BENZIMIDAZOLE, AND 2-(ARALKYLSULFINYL)BENZIMIDAZOLE WITH THIOLS - A CONVENIENT SYNTHESIS OF UNSYMMETRICAL DISULFIDES [J].
GRABER, DR ;
MORGE, RA ;
SIH, JC .
JOURNAL OF ORGANIC CHEMISTRY, 1987, 52 (20) :4620-4622
[7]   NA-DIRECTED ALKYLATING-AGENTS .6. SYNTHESIS AND ANTITUMOR-ACTIVITY OF DNA MINOR GROOVE-TARGETED ANILINE MUSTARD ANALOGS OF PIBENZIMOL (HOECHST-33258) [J].
GRAVATT, GL ;
BAGULEY, BC ;
WILSON, WR ;
DENNY, WA .
JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (25) :4338-4345
[8]  
HASEGAWA H, 1974, Patent No. 198
[9]  
Jayashankara B, 2008, ARKIVOC, P75
[10]   Substituted 2,5'-bi-1H-benzimidazoles: Topoisomerase I inhibition and cytotoxicity [J].
Kim, JS ;
Gatto, B ;
Yu, C ;
Liu, A ;
Liu, LF ;
LaVoie, EJ .
JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (04) :992-998