C-TYPE NATRIURETIC PEPTIDE IS A GROWTH INHIBITOR OF RAT VASCULAR SMOOTH-MUSCLE CELLS

被引：190

作者：

FURUYA, M

YOSHIDA, M

HAYASHI, Y

OHNUMA, N

MINAMINO, N

KANGAWA, K

MATSUO, H

机构：

[1] NATL CARDIOVASC CTR,RES INST,SUITA,OSAKA 565,JAPAN

[2] SUNTORY INST BIOMED RES,MISHIMA,OSAKA 618,JAPAN

[3] SUNTORY BIOPHARMA TECH CTR,TOKYO,GUNMA 37005,JAPAN

[4] MIYAZAKI MED COLL,DEPT BIOCHEM,MIYAZAKI 88916,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 177卷 / 03期

关键词：

D O I：

10.1016/0006-291X(91)90627-J

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

C-type natriuretic peptide (CNP) which potently stimulates particulate guanylate cyclase activity in cultured rat vascular smooth muscle cells (VSMC) inhibited serum-induced DNA synthesis of the cells 10-fold more effectively than α-human atrial natriuretic peptide (α-hANP). The inhibitory effect of CNP was mimicked by 8-bromo-cGMP. The proliferation of VSMC was also suppressed by CNP more potently than α-hANP, while the peptide was less active for cGMP augmentation and for vasorelaxation than α-hANP in isolated rat aorta. These results suggest that CNP may be a growth regulating factor of VSMC rather than a vasodilator. © 1991.

引用

收藏

页码：927 / 931

页数：5

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