ZERO ORDER RELEASE FROM GLASSY HYDROGELS .2. MATRIX EFFECTS

被引：10

作者：

VYAVAHARE, NR ^{[1
]}

KULKARNI, MG ^{[1
]}

MASHELKAR, RA ^{[1
]}

机构：

[1] NATL CHEM LAB,DIV CHEM ENGN,POLYMER SCI & ENGN GRP,POONA 411008,MAHARASHTRA,INDIA

来源：

JOURNAL OF MEMBRANE SCIENCE | 1990年 / 54卷 / 1-2期

关键词：

D O I：

10.1016/S0376-7388(00)82080-3

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

A series of copolymers of 2 -hydroxyethyl methacrylate (HEMA) with a hydrophobic monomer, methoxyethyl methacrylate (MEMA), and a hydrophilic monomer, methoxyethoxyethyl methacrylate (MEEMA), was evaluated as matrices for the release of benzoic acid and theophylline. The results are discussed in the context of the criteria developed in the literature for zero order release from glassy hydrogels. Release of theophylline from a p (HEMA-MEMA) matrix containing 22% MEMA followed zero order kinetics. Benzoic acid was released at constant rate from all the matrices. © 1990.

引用

页码：205 / 220

页数：16

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