EFFECT OF 15(R)-15-METHYL PROSTAGLANDIN-E2 ON MEAL-STIMULATED GASTRIC-ACID SECRETION, SERUM GASTRIN, AND PANCREATIC POLYPEPTIDE IN DUODENAL-ULCER PATIENTS

被引：56

作者：

PETERSON, W

FELDMAN, M

TAYLOR, I

BREMER, M

机构：

[1] UPJOHN CO,KALAMAZOO,MI 49001

[2] UNIV TEXAS,HLTH SCI CTR,SW MED SCH,DEPT INTERNAL MED,DALLAS,TX 75235

[3] UNIV CALIF LOS ANGELES,DEPT INTERNAL MED,LOS ANGELES,CA 90024

来源：

DIGESTIVE DISEASES AND SCIENCES | 1979年 / 24卷 / 05期

关键词：

D O I：

10.1007/BF01297125

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The effects of 100-μg doses of 15(R)-15-methyl prostaglandin E2 on meal-stimulated acid secretion, serum gastrin, and pancreatic polypeptide concentrations were measured in patients with duodenal ulcer. The drug given in encapsulated or unencapsulated form significantly reduced gastric acid secretion by 59% or 70%, respectively. Rises in serum gastrin and pancreatic polypeptide concentrations after the meal were significantly blunted by 15(R)-15-methyl prostaglandin E2. This dose of prostaglandin led to no side effects and merits clinical evaluation in the treatment of peptic ulcer disease. © 1979 Digestive Disease Systems, Inc.

引用

页码：381 / 384

页数：4

共 19 条

[1]

BLOOM SR, 1978, GASTROENTEROLOGY, V74, P1012

[2] EFFECT OF 15-(R)-15-METHYL PROSTAGLANDIN-E2 ON GASTRIC-ACID SECRETION IN DUODENAL-ULCER PATIENTS [J].