Piperacillin-Induced Immune Hemolytic Anemia in an Adult with Cystic Fibrosis

被引：20
作者：
Bandara, Mahesh [1 ,2 ]
Seder, David B. [1 ,2 ]
Garratty, George [3 ]
Leger, Regina M. [3 ]
Zuckerman, Jonathan B. [1 ,2 ]
机构：
[1] Univ Vermont, Dept Med, 22 Bramhall St, Portland, ME 04102 USA
[2] Maine Med Ctr, Portland, ME 04102 USA
[3] Amer Red Cross Blood Serv, Pomona, CA 91768 USA
来源：
CASE REPORTS IN MEDICINE | 2010年 / 2010卷
关键词：
D O I：
10.1155/2010/161454
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We report a case of drug-induced immune hemolytic anemia (DIIHA) in an adult female with cystic fibrosis (CF), complicating routine treatment of a pulmonary exacerbation with intravenous piperacillin-tazobactam. Workup revealed a positive direct antiglobulin test (DAT) due to red blood cell (RBC)-bound IgG and C3 and piperacillin antibodies detectable in the patient's serum. The potential influence of CF transmembrane conductance regulatormutations on the severity of DIIHA is discussed. This report illustrates the importance of early identification of DIIHA, a rare complication of a commonly utilized medication in CF.
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