MODULATION OF KC/GRO PROTEIN (INTERLEUKIN-8 RELATED PROTEIN IN RODENTS) RELEASE FROM HEPATOCYTES BY BIOLOGICALLY-ACTIVE MEDIATORS

被引：27

作者：

SHIRATORI, Y ^{[1
]}

HIKIBA, Y ^{[1
]}

MAWET, E ^{[1
]}

NIWA, Y ^{[1
]}

MATSUMURA, M ^{[1
]}

KATO, N ^{[1
]}

SHIINA, S ^{[1
]}

TADA, M ^{[1
]}

KOMATSU, Y ^{[1
]}

KAWABE, T ^{[1
]}

YOSHIDA, H ^{[1
]}

OKANO, K ^{[1
]}

OMATA, M ^{[1
]}

机构：

[1] UNIV TOKYO, FAC MED, DEPT INTERNAL MED 2, TOKYO 113, JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 203卷 / 03期

关键词：

D O I：

10.1006/bbrc.1994.2340

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Modulation of the release of KC/gro protein (a chemoattractant for neutrophils; IL-8 related protein in rodents) from isolated hepatocytes after stimulation with biologically active mediators was investigated. The release of KC/gro protein from hepatocytes of control rats was enhanced by stimulation with lipopolysaccharide, IL-1beta or TNF-alpha in a dose dependent manner, but was not enhanced by IL-6. In contrast, although spontaneous release of KC/gro protein from the hepatocytes of chronically ethanol-fed rats was markedly enhanced as compared with control rats, the relative increase by stimulation with lipopolysaccharide, IL 1beta or TNF-alpha was significantly smaller than in controls. These findings suggest that the regulation of hepatocyte KC/gro protein production might be disturbed in chronically ethanol-fed rats. (C) 1994 Academic Press, Inc.

引用

页码：1398 / 1403

页数：6

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