AGE-DEPENDENT CHANGES IN THE MITOCHONDRIAL F0F1 ATP SYNTHASE

被引：35
|
作者：
GUERRIERI, F
CAPOZZA, G
KALOUS, M
ZANOTTI, F
DRAHOTA, Z
PAPA, S
机构：
[1] UNIV BARI, CNR, CTR STUDY MITOCHONDRIA & ENERGY METAB, I-70124 BARI, ITALY
[2] CZECHOSLOVAK ACAD SCI, INST PHYSIOL, CS-11142 PRAGUE 1, CZECHOSLOVAKIA
来源：
ARCHIVES OF GERONTOLOGY AND GERIATRICS | 1992年 / 14卷 / 03期
关键词：
AGING; F0F1 ATP SYNTHASE; HEART MITOCHONDRIA; ENZYME; F0F1 ATP SYNTHASE (EC 3.6.1.34);
D O I：
10.1016/0167-4943(92)90029-4
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
The age dependence of ATP hydrolase activity and oligomycin sensitive passive proton conduction in sonicated submitochondrial particles of rat brain and rat heart has been investigated. The results show an increase of V(max) of the ATP hydrolase activity and decrease of oligomycin sensitive passive proton conduction with increase of the age of rats from 3 to 6 months. Decrease of ATPase activity and increase of oligomycin sensitive proton conduction occur with further aging to 24 months. Immunoblot analysis shows that both the F1 and F(o) contents of mitochondria vary with the age of rats, the former exhibiting relatively larger changes.
引用
收藏
页码：299 / 308
页数：10
相关论文
共 50 条
  • [1] AGE-DEPENDENT CHANGES IN MITOCHONDRIAL F0F1 ATP SYNTHASE IN REGENERATING RAT-LIVER
    GUERRIERI, F
    KALOUS, M
    CAPOZZA, G
    MUOLO, L
    DRAHOTA, Z
    PAPA, S
    BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL, 1994, 33 (01): : 117 - 129
  • [2] AGE-RELATED-CHANGES OF MITOCHONDRIAL F0F1 ATP SYNTHASE
    GUERRIERI, F
    CAPOZZA, G
    KALOUS, M
    PAPA, S
    ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1992, 671 : 395 - 402
  • [3] FUNCTIONAL AND IMMUNOLOGICAL CHARACTERIZATION OF MITOCHONDRIAL F0F1 ATP-SYNTHASE
    GUERRIERI, F
    KOPECKY, J
    ZANOTTI, F
    ORGANELLES IN EUKARYOTIC CELLS: MOLECULAR STRUCTURE AND INTERACTIONS, 1989, : 197 - 208
  • [4] The coupling regions of F0F1 ATP synthase
    Kellner, E
    Licher, T
    Lill, H
    PHOTOSYNTHESIS: MECHANISMS AND EFFECTS, VOLS I-V, 1998, : 1739 - 1742
  • [5] Rotational coupling in the F0F1 ATP synthase
    Nakamoto, RK
    Ketchum, CJ
    Al-Shawi, MK
    ANNUAL REVIEW OF BIOPHYSICS AND BIOMOLECULAR STRUCTURE, 1999, 28 : 205 - 234
  • [6] Mechanisms of active transport in the F0F1 ATP synthase
    Nakamoto, RK
    JOURNAL OF MEMBRANE BIOLOGY, 1996, 151 (02): : 101 - 111
  • [7] PLANT MITOCHONDRIAL F0F1 ATP SYNTHASE - IDENTIFICATION OF THE INDIVIDUAL SUBUNITS AND PROPERTIES OF THE PURIFIED SPINACH LEAF MITOCHONDRIAL ATP SYNTHASE
    HAMASUR, B
    GLASER, E
    EUROPEAN JOURNAL OF BIOCHEMISTRY, 1992, 205 (01): : 409 - 416
  • [8] A column centrifugation method for the reconstitution in liposomes of the mitochondrial F0F1 ATP synthase ATPase
    VazquezContreras, E
    deGomezPuyou, MT
    Dreyfus, G
    PROTEIN EXPRESSION AND PURIFICATION, 1996, 7 (02) : 155 - 159
  • [9] PEPTIDE ANALYSES OF THE INHIBITOR PROTEIN OF THE MITOCHONDRIAL F0F1 ATP-SYNTHASE (IF1)
    LEBOWITZ, MS
    LIU, WS
    PEDERSEN, PL
    FASEB JOURNAL, 1993, 7 (07): : A1105 - A1105
  • [10] Molecular features of energy coupling in the F0F1 ATP synthase
    Nakamoto, RK
    NEWS IN PHYSIOLOGICAL SCIENCES, 1999, 14 : 40 - 46
12345