GENE-THERAPY TARGETED BY IONIZING-RADIATION

被引：54
作者：
WEICHSELBAUM, RR
HALLAHAN, DE
SUKHATME, VP
KUFE, DW
机构：
[1] UNIV CHICAGO,HOWARD HUGHES MED INST,DEPT MED,CHICAGO,IL 60637
[2] HARVARD UNIV,SCH MED,DANA FARBER CANC INST,BOSTON,MA 02115
来源：
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 1992年 / 24卷 / 03期
关键词：
GENE THERAPY; X-RAYS; TRANSCRIPTION;
D O I：
10.1016/0360-3016(92)91075-X
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Gene therapy used for the treatment of neoplastic diseases is not well localized. Ionizing radiation can be used to activate the transcription of exogenous genes that encode cytotoxic proteins. This may be accomplished through the use of radiation responsive elements distal to the transcription start site of such genes. We discuss this concept and describe a technique which can be used to amplify the signal initiated by localized radiation therapy. These techniques may be used to target gene therapy during the treatment of human neoplasms.
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页码：565 / 567
页数：3
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