THE GENE FOR AARSKOG SYNDROME IS LOCATED BETWEEN DXS255 AND DXS566 (XP 11.2-XQ13)

被引：26

作者：

PORTEOUS, MEM ^{[1
]}

CURTIS, A ^{[1
]}

LINDSAY, S ^{[1
]}

WILLIAMS, O ^{[1
]}

GOUDIE, D ^{[1
]}

KAMAKARI, S ^{[1
]}

BHATTACHARYA, SS ^{[1
]}

机构：

[1] UNIV CAMBRIDGE,DEPT GENET,CAMBRIDGE,ENGLAND

来源：

GENOMICS | 1992年 / 14卷 / 02期

关键词：

D O I：

10.1016/S0888-7543(05)80219-8

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Aarskog syndrome has been mapped to Xq13 on the basis of a patient carrying an Xq13:8p21.2 translocation. We have identified a new microsatellite marker in a clone mapping to this region (HX60;DXS566). Using primers flanking this microsatellite along with primers detecting a microsatellite at PGK1P1 and DXS255, and DXS72, we have performed a multipoint analysis in a large kindred with Aarskog syndrome. Our results suggest that the Aarskog locus lies proximal to Xq13. This is supported by the recent redefining of the break-point of the original translocation as between DXS14 (Xp11.21-p11.1) and DXS146 (Xp11.23-p11.22). © 1992 Academic Press, Inc. All rights reserved.

引用

页码：298 / 301

页数：4

共 18 条

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