MOLECULAR DISSECTION OF THE SECRETORY PATHWAY

被引:937
作者
ROTHMAN, JE [1 ]
ORCI, L [1 ]
机构
[1] UNIV GENEVA, INST HISTOL & EMBRYOL, DEPT MORPHOL, CH-1211 GENEVA 4, SWITZERLAND
关键词
D O I
10.1038/355409a0
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
A combination of biochemistry in animal cell-free systems and genetics in yeast is revealing the molecular machinery of the secretory pathway of eukaryotes. Transporting vesicles have a simple coat structure and employ a general mechanism for fusion that is conserved in evolution. © 1992 Nature Publishing Group.
引用
收藏
页码:409 / 415
页数:7
相关论文
共 110 条
[81]   ENDOCYTOSIS IN YEAST - SEVERAL OF THE YEAST SECRETORY MUTANTS ARE DEFECTIVE IN ENDOCYTOSIS [J].
RIEZMAN, H .
CELL, 1985, 40 (04) :1001-1009
[82]  
ROTHMAN JE, 1986, CELL, V46, P5, DOI 10.1016/0092-8674(86)90852-4
[83]   THE GOLGI-APPARATUS - 2 ORGANELLES IN TANDEM [J].
ROTHMAN, JE .
SCIENCE, 1981, 213 (4513) :1212-1219
[84]  
ROTHMAN JE, 1987, J BIOL CHEM, V262, P12502
[85]   PROTEIN SORTING BY SELECTIVE RETENTION IN THE ENDOPLASMIC-RETICULUM AND GOLGI STACK [J].
ROTHMAN, JE .
CELL, 1987, 50 (04) :521-522
[86]   TRANSPORT OF PROTEIN BETWEEN CYTOPLASMIC MEMBRANES OF FUSED CELLS - CORRESPONDENCE TO PROCESSES RECONSTITUTED IN A CELL-FREE SYSTEM [J].
ROTHMAN, JE ;
URBANI, LJ ;
BRANDS, R .
JOURNAL OF CELL BIOLOGY, 1984, 99 (01) :248-259
[87]   INTERCOMPARTMENTAL TRANSPORT IN THE GOLGI-COMPLEX IS A DISSOCIATIVE PROCESS - FACILE TRANSFER OF MEMBRANE-PROTEIN BETWEEN 2 GOLGI POPULATIONS [J].
ROTHMAN, JE ;
MILLER, RL ;
URBANI, LJ .
JOURNAL OF CELL BIOLOGY, 1984, 99 (01) :260-271
[88]   RECONSTITUTION OF PROTEIN-TRANSPORT FROM THE ENDOPLASMIC-RETICULUM TO THE GOLGI-COMPLEX IN YEAST - THE ACCEPTOR GOLGI COMPARTMENT IS DEFECTIVE IN THE SEC23 MUTANT [J].
RUOHOLA, H ;
KABCENELL, AK ;
FERRONOVICK, S .
JOURNAL OF CELL BIOLOGY, 1988, 107 (04) :1465-1476
[89]   A RAS-LIKE PROTEIN IS REQUIRED FOR A POST-GOLGI EVENT IN YEAST SECRETION [J].
SALMINEN, A ;
NOVICK, PJ .
CELL, 1987, 49 (04) :527-538
[90]   PRE-GOLGI AND POST-GOLGI VACUOLES OPERATE IN THE TRANSPORT OF SEMLIKI FOREST VIRUS MEMBRANE-GLYCOPROTEINS TO THE CELL-SURFACE [J].
SARASTE, J ;
KUISMANEN, E .
CELL, 1984, 38 (02) :535-549