MECHANISMS OF INSULIN RESISTANCE IN HUMAN OBESITY - EVIDENCE FOR RECEPTOR AND POSTRECEPTOR DEFECTS

被引:621
作者
KOLTERMAN, OG [1 ]
INSEL, J [1 ]
SAEKOW, M [1 ]
OLEFSKY, JM [1 ]
机构
[1] VET ADM HOSP, DENVER, CO 80220 USA
关键词
D O I
10.1172/JCI109790
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
引用
收藏
页码:1272 / 1284
页数:13
相关论文
共 45 条
[1]   DEFECT IN INSULIN BINDING TO RECEPTORS IN OBESE MAN - AMELIORATION WITH CALORIE RESTRICTION [J].
ARCHER, JA ;
GORDEN, P ;
ROTH, J .
JOURNAL OF CLINICAL INVESTIGATION, 1975, 55 (01) :166-174
[2]   FLUCTUATIONS IN AFFINITY AND CONCENTRATION OF INSULIN RECEPTORS ON CIRCULATING MONOCYTES OF OBESE PATIENTS - EFFECTS OF STARVATION, REFEEDING, AND DIETING [J].
BAR, RS ;
GORDEN, P ;
ROTH, J ;
KAHN, CR ;
DEMEYTS, P .
JOURNAL OF CLINICAL INVESTIGATION, 1976, 58 (05) :1123-1135
[3]  
BJORNTORP P, 1971, EUR J CLIN INVEST, V1, P480, DOI 10.1111/j.1365-2362.1971.tb00559.x
[4]   EFFECTS OF FEEDING STATES ON LIPID RADIOACTIVITY IN LIVER, MUSCLE AND ADIPOSE TISSUE AFTER INJECTION OF LABELLED GLUCOSE IN RAT [J].
BJORNTORP, P ;
KROTKIEWSKI, M ;
LARSSON, B ;
SOMLOSZU.Z .
ACTA PHYSIOLOGICA SCANDINAVICA, 1970, 80 (01) :29-+
[5]  
BJURULF P, 1959, Acta Med Scand Suppl, V349, P1
[6]   PORTAL AND PERIPHERAL VEIN IMMUNOREACTIVE INSULIN CONCENTRATIONS BEFORE AND AFTER GLUCOSE INFUSION [J].
BLACKARD, WG ;
NELSON, NC .
DIABETES, 1970, 19 (05) :302-&
[7]   EFFECT OF GLUCAGON ON GLUCOSE PRODUCTION DURING INSULIN DEFICIENCY IN DOG [J].
CHERRINGTON, AD ;
LACY, WW ;
CHIASSON, JL .
JOURNAL OF CLINICAL INVESTIGATION, 1978, 62 (03) :664-677
[8]  
CHIASSON JL, 1977, FED PROC, V36, P229
[9]   CELLULAR BASIS OF INSULIN INSENSITIVITY IN LARGE RAT ADIPOCYTES [J].
CZECH, MP .
JOURNAL OF CLINICAL INVESTIGATION, 1976, 57 (06) :1523-1532
[10]   INSULIN BINDING TO MONOCYTES AND INSULIN ACTION IN HUMAN OBESITY, STARVATION, AND REFEEDING [J].
DEFRONZO, RA ;
SOMAN, V ;
SHERWIN, RS ;
HENDLER, R ;
FELIG, P .
JOURNAL OF CLINICAL INVESTIGATION, 1978, 62 (01) :204-213