CSF BACLOFEN LEVELS AFTER INTRATHECAL ADMINISTRATION IN SEVERE SPASTICITY

被引：49
作者：
SALLERINCAUTE, B
LAZORTHES, Y
MONSARRAT, B
CROS, J
BASTIDE, R
机构：
[1] FAC SCI PHARMACEUT TOULOUSE,PHARM GALEN LAB,TOULOUSE,FRANCE
[2] CHU TOULOUSE RANGUEIL,NEUROCHIRURG CLIN,NEUROCHIRURG & NEUROBIOL APPL LAB,TOULOUSE,FRANCE
来源：
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 1991年 / 40卷 / 04期
关键词：
BACLOFEN; SEVERE SPASTICITY; PHARMACOKINETICS; CSF; INTRATHECAL INJECTION;
D O I：
10.1007/BF00265844
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The pharmacokinetic parameters in the CSF of baclofen given to 4 patients as an intrathecal bolus are reported. Considerable inter-individual variability in the parameters was observed. The elimination half-life ranged from 0.9 to 5 h and the clearance from 0.013 to 0.081.h-1. In order to optimize treatment, it is suggested that CSF baclofen levels be matched to changes in Hoffman's monosynaptic reflex (H reflex).
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页码：363 / 365
页数：3
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