Suppression of postsurgical recurrence of hepatocellular carcinoma treated with autologous formalin-fixed tumor vaccine, with special reference to glypican-3

被引：7

作者：

Kawashima, Issei ^{[1
]}

Kawashima, Yuri ^{[1
,2
]}

Matsuoka, Yasuo ^{[1
]}

Fujise, Kiyotaka ^{[3
]}

Sakai, Hideki ^{[4
]}

Takahashi, Mari ^{[5
]}

Yoshikawa, Toshiaki ^{[5
]}

Nakatsura, Tetsuya ^{[5
]}

Ishihara, Takeshi ^{[6
]}

Ohno, Tadao ^{[6
]}

机构：

[1] Hikarigaoka Clin, Green Town Hikarigaoka 4-10-10, Kashiwa, Chiba 2770062, Japan

[2] Natl Cheng Kung Univ, Tainan 701, Taiwan

[3] Fujise Internal Med Clin, Kashiwa, Chiba 2770075, Japan

[4] Kashiwa Municipal Hosp, Kashiwa, Chiba 2770825, Japan

[5] Natl Canc Ctr, Exploratory Oncol Res & Clin Trial Ctr, Kashiwa, Chiba 2778577, Japan

[6] Cell Med Inc, Tsukuba, Ibaraki 3050047, Japan

来源：

CLINICAL CASE REPORTS | 2015年 / 3卷 / 06期

关键词：

Cytotoxic T lymphocyte; glypican-3; hepatocellular carcinoma; tumor vaccine;

D O I：

10.1002/ccr3.279

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Autologous formalin-fixed tumor vaccine (AFTV) suppressed re-recurrence for more than 32 months of multiple-recurrent hepatocellular carcinoma based on hepatitis C virus-induced liver cirrhosis in a case with previous recurrence interval, 51-, 28-, 12-, and 4-months. We detected glypican-3-specific cytotoxic T lymphocytes in the peripheral blood at 12 months after AFTV.

引用

页码：444 / 447

页数：4

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