Selenoprotein P in colitis-associated carcinoma

被引：7

作者：

Short, Sarah P. ^{[1
,2
,3
]}

Whitten-Barrett, Caitlyn ^{[1
,2
,3
]}

Williams, Christopher S. ^{[1
,2
,3
,4
]}

机构：

[1] Vanderbilt Univ, Dept Med, Div Gastroenterol, 221 Kirkland Hall, Nashville, TN 37235 USA

[2] Vanderbilt Univ, Dept Canc Biol, 221 Kirkland Hall, Nashville, TN 37235 USA

[3] Vanderbilt Ingram Canc Ctr, Nashville, TN 37232 USA

[4] Vet Affairs Tennessee Valley Hlth Care Syst, Nashville, TN 37212 USA

来源：

MOLECULAR & CELLULAR ONCOLOGY | 2016年 / 3卷 / 03期

关键词：

Cancer; IBD; selenoprotein P; SEPP1; ulcerative colitis;

D O I：

10.1080/23723556.2015.1075094

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Patients with inflammatory bowel disease are often deficient in micronutrients such as selenium and have an increased risk of colon cancer. We tested whether the selenium transport protein, selenoprotein P, could modify colitis-associated cancer. Our results indicate that global SEPP1 haploinsufficiency augments tumorigenesis and mediates oxidative damage in the intestine.

引用

页数：3

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