Oxaliplatin-induced hepatic sinusoidal obstruction syndrome in a patient with gastric cancer: A case report

被引：16
作者：
Liu, Fang [1 ]
Cao, Xin [2 ]
Ye, Jin [2 ]
Pan, Xiaoli [2 ]
Kan, Xuefeng [3 ]
Song, Yuhu [2 ]
机构：
[1] HunAlong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Inst Hematol, Wuhan 430022, Hubei, Peoples R China
[2] HunAlong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Div Gastroenterol, 1277 Jiefang Ave, Wuhan 430022, Hubei, Peoples R China
[3] HunAlong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Radiol, Wuhan 430022, Hubei, Peoples R China
来源：
MOLECULAR AND CLINICAL ONCOLOGY | 2018年 / 8卷 / 03期
基金：
中国国家自然科学基金;
关键词：
oxaliplatin; sinusoidal obstruction syndrome; hepatic sinusoidal obstruction syndrome;
D O I：
10.3892/mco.2017.1540
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Oxaliplatin is a platinum-based antineoplastic agent used in cancer chemotherapy. Oxaliplatin-induced hepatic sinusoidal obstruction syndrome (HSOS) has been reported in the context of chemotherapy for liver metastasis of colorectal cancer. However, to the best of our knowledge, there is no report of oxaliplatin-associated HSOS in patients with gastric cancer. The present study reported a patient with gastric cancer who received proximal gastrectomy and oxaliplatin-containing chemotherapy. Contrast-enhanced computed tomography revealed that liver parenchyma appeared heterogeneous and demonstrated hypoattenuation in the portal phase. In dynamic contrast-enhanced magnetic resonance imaging, hypointense heterogeneity was demonstrated in the portal-venous phase. Pathological examination indicated distinctive multifocal sinusoidal dilatation. In conclusion, the present report indicated a case of oxaliplatin-induced HSOS in a patient with gastric cancer who received oxaliplatin-contained chemotherapy.
引用
收藏
页码：453 / 456
页数：4
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