LINKAGE RELATIONSHIPS BETWEEN DXS105, DXS98, AND OTHER POLYMORPHIC DNA MARKERS FLANKING THE FRAGILE-X LOCUS

被引：4

作者：

CARPENTER, NJ

THIBODEAU, SN

BROWN, WT

机构：

[1] MAYO CLIN & MAYO FDN,DEPT LAB MED,ROCHESTER,MN 55905

[2] N SHORE UNIV HOSP,DEPT HUMAN GENET,MANHASSET,NY 11030

来源：

AMERICAN JOURNAL OF MEDICAL GENETICS | 1991年 / 38卷 / 2-3期

关键词：

FACTOR-IX; FRAXA; RISK ASSESSMENT;

D O I：

10.1002/ajmg.1320380237

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We report on linkage data between DXS105, DXS98, the locus for the fragile X syndrome (FRAXA), and 3 other polymorphic loci that flank the FRAXA locus. An analysis was undertaken to determine the relative positions of DXS105 and DXS98 and to test the assignment of DXS105 to a location proximal and closely linked to FRAXA. In this study of fragile X fra(X) syndrome families, the DXS105 locus was calculated to be proximal to FRAXA with a maximum lod score of 10.36 at THETA = 0.08. DXS105 was also shown to be closely linked to the gene for factor IX (F9)(Z = 11.84 at THETA = 0.08) and to DXS98 (Z = 4.91 at THETA = 0.04). The order of the loci proximal to FRAXA is most likely centromere-factor IX-DXS105-DXS98-FRAXA-telomere. The use of DXS105 and DXS98 in clinical investigations should significantly increase the accuracy of risk assessment in informative fragile X families.

引用

页码：349 / 353

页数：5

共 20 条

[1]

ARVEILER B, 1988, AM J HUM GENET, V42, P380

[2]

BROWN WT, 1987, LANCET, V1, P280

[3] MULTILOCUS ANALYSIS OF THE FRAGILE-X SYNDROME [J].

BROWN, WT ;

GROSS, A ;

CHAN, C ;

JENKINS, EC ;

MANDEL, JL ;

OBERLE, I ;

ARVEILER, B ;

NOVELLI, G ;

THIBODEAU, S ;

HAGERMAN, R ;

SUMMERS, K ;

TURNER, G ;

WHITE, BN ;

MULLIGAN, L ;

FORSTERGIBSON, C ;

HOLDEN, JJA ;

ZOLL, B ;

KRAWCZAK, M ;

GOONEWARDENA, P ;

GUSTAVSON, KH ;

PETTERSSON, U ;

HOLMGREN, G ;

SCHWARTZ, C ;

HOWARDPEEBLES, PN ;

MURPHY, P ;

BREG, WR ;

VEENEMA, H ;

CARPENTER, NJ .

HUMAN GENETICS, 1988, 78 (03) :201-205

[4] FURTHER EVIDENCE FOR GENETIC-HETEROGENEITY IN THE FRAGILE-X SYNDROME [J].

BROWN, WT ;

JENKINS, EC ;

GROSS, AC ;

CHAN, CB ;

KRAWCZUN, MS ;

DUNCAN, CJ ;

SKLOWER, SL ;

FISCH, GS .

HUMAN GENETICS, 1987, 75 (04) :311-321

[5] A NEW DNA PROBE PROXIMAL TO AND CLOSELY LINKED TO FRAGILE-X [J].

CARPENTER, NJ ;

VEENEMA, H ;

BAKKER, E ;

HOFKER, MH ;

PEARSON, PL .

AMERICAN JOURNAL OF MEDICAL GENETICS, 1987, 27 (03) :731-732

[6]

CONNOR JM, 1987, J MED GENET, V24, P635

[7] IMPROVED DNA MARKERS FOR EFFICIENT ANALYSIS OF FRAGILE-X FAMILIES [J].

HEILIG, R ;

OBERLE, I ;

ARVEILER, B ;

HANAUER, A ;

VIDAUD, M ;

MANDEL, JL .

AMERICAN JOURNAL OF MEDICAL GENETICS, 1988, 30 (1-2) :543-550

[8]

HOFKER MH, 1987, AM J HUM GENET, V40, P312

[9]

LATHROP GM, 1984, AM J HUM GENET, V36, P460

[10] LINKAGE BETWEEN THE FRAGILE-X AND F9, DXS52 (ST14), DXS98 (4D-8) AND DXS105 (CX55.7) [J].

MULLEY, J ;

TURNER, G ;

BAIN, S ;

SUTHERLAND, GR .

AMERICAN JOURNAL OF MEDICAL GENETICS, 1988, 30 (1-2) :567-580

← 1 2 →