IMMUNODEFICIENT MICE RECOVER FROM INFECTION WITH VACCINIA VIRUS EXPRESSING INTERFERON-GAMMA

被引：118

作者：

KOHONENCORISH, MRJ ^{[1
]}

KING, NJC ^{[1
]}

WOODHAMS, CE ^{[1
]}

RAMSHAW, IA ^{[1
]}

机构：

[1] UNIV SYDNEY,DEPT ANAT,SYDNEY,NSW 2006,AUSTRALIA

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1990年 / 20卷 / 01期

关键词：

D O I：

10.1002/eji.1830200123

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recombinant vaccinia viruses (VV)‐encoding murine interferon‐γ (IFN‐γ) were constructed and the effect of virus‐encoded IFN‐γ on the immune response towards VV in vivo investigated. In athymic nude mice and sublethally irradiated euthymic mice, IFN‐γ expression by VV enabled the mice to recover from the infection, whereas mice infected with the control virus died. In normal CBA/H mice also, the growth of VV was greatly reduced and it was cleared faster from mouse organs than the control virus. Natural killer (NK) cell responses in these mice were not enhanced suggesting that this recovery is not NK cell mediated. Other possible mechanisms and implications of this observation are discussed. Copyright © 1990 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim

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页码：157 / 161

页数：5

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