EFFECTS OF CAFFEINE ON SISTER-CHROMATID EXCHANGES (SCE) INVIVO

被引：27
作者：
BASLER, A
BACHMANN, U
ROSZINSKYKOCHER, G
ROHRBORN, G
机构：
[1] Department of Human Genetics and Anthropology, D-4000 Düsseldorf 1, Universitätsstr. 1
来源：
MUTATION RESEARCH | 1979年 / 59卷 / 02期
关键词：
D O I：
10.1016/0027-5107(79)90159-3
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Chinese hamsters were twice treated with caffeine via stomach tube. The single doses were either 20, 100, 200 or 400 mg per kg body weight. A dose-dependent increase was observed in the frequencies of SCE induced in vivo in bone-marrow cells. Two intraperitoneal injections of the chemical mutagens, cyclophosphamide or benzo[a]pyrene, led to a pronounced increase of the frequency of SCE. Simultaneous applications of the chemical mutagens and caffeine decreased the rate of SCE. The effect of caffeine per se to induce SCE, and the mechanisms by which caffeine reduces the level of SCE induced by chemical mutagens are discussed. © 1979.
引用
收藏
页码：209 / 214
页数：6
相关论文
共 18 条
[1]   DOSE-DEPENDENCE OF SISTER CHROMATID EXCHANGES INDUCED BY 3 HYDROCARBONS, IN INVIVO BONE-MARROW TEST WITH CHINESE HAMSTERS [J].
BAYER, U ;
BAUKNECHT, T .
EXPERIENTIA, 1977, 33 (01) :25-25
[2]   CHEMICAL MUTAGENESIS IN MAMMALS - CHINESE HAMSTER BONE MARROW AS AN IN-VIVO TEST SYSTEM - HEMATOLOGICAL FINDINGS AFTER TREATMENT WITH TRENIMON [J].
BOLLER, K ;
SCHMID, W .
HUMANGENETIK, 1970, 11 (01) :35-&
[3]  
FREI JV, 1975, MUTAT RES, V30, P89
[4]   MECHANISMS FOR SISTER CHROMATID EXCHANGES AND THEIR RELATION TO PRODUCTION OF CHROMOSOMAL-ABERRATIONS [J].
KATO, H .
CHROMOSOMA, 1977, 59 (03) :179-191
[5]   INDUCTION OF SISTER CHROMATID EXCHANGES BY CHEMICAL MUTAGENS AND ITS POSSIBLE RELEVANCE TO DNA-REPAIR [J].
KATO, H .
EXPERIMENTAL CELL RESEARCH, 1974, 85 (02) :239-247
[6]  
Kihlman B.A., 1977, CAFFEINE CHROMOSOMES
[7]   SISTER CHROMATID EXCHANGES IN VICIA-FABA .2. EFFECTS OF THIOTEPA, CAFFEINE AND 8-ETHOXYCAFFEINE ON FREQUENCY OF SCES [J].
KIHLMAN, BA .
CHROMOSOMA, 1975, 51 (01) :11-18
[8]  
KIHLMAN BA, 1978, HEREDITAS, V88, P35
[9]   KOFFEIN- UND THEOPHYLLINMUTAGENESE BEI ZELL- UND LEUKOZYTENKULTUREN DES MENSCHEN [J].
OSTERTAG, W .
MUTATION RESEARCH, 1966, 3 (03) :249-&
[10]   EFFECT OF CAFFEINE ON SISTER CHROMATID EXCHANGES AND CHROMOSOMAL-ABERRATIONS INDUCED BY MUTAGENS IN CHINESE-HAMSTER CELLS [J].
PALITTI, F ;
BECCHETTI, A .
MUTATION RESEARCH, 1977, 45 (01) :157-159
12