THE SUZUKI REACTION IN STEREOCONTROLLED POLYENE SYNTHESIS - RETINOL (VITAMIN-A), ITS 9-DEMETHYL AND/OR 13-DEMETHYL ANALOGS, AND RELATED 9-DEMETHYL-DIHYDRORETINOIDS

被引：77

作者：

TORRADO, A ^{[1
]}

IGLESIAS, B ^{[1
]}

LOPEZ, S ^{[1
]}

DELERA, AR ^{[1
]}

机构：

[1] UNIV SANTIAGO DE COMPOSTELA, DEPT QUIM ORGAN, E-15706 SANTIAGO, SPAIN

来源：

TETRAHEDRON | 1995年 / 51卷 / 08期

关键词：

D O I：

10.1016/0040-4020(94)01108-C

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new synthesis of retinol (vitamin A) and 9- and/or 13-demethylretinols, with essentially complete control of regio- and stereochemistry, is described which is based on the thallium-accelerated, palladium-catalyzed cross-coupling reactions of (E)-1-alkenylboronic acids and (E)-1-alkenyl iodides (Suzuki reaction). The procedure has also been extended to the stereocontrolled synthesis of a series of 9-demethyl-dihydroretinoids of potential biological interest.

引用

页码：2435 / 2454

页数：20

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