EVALUATION OF DEOXYRIBONUCLEIC-ACID PLOIDY AND S-PHASE FRACTION AS PROGNOSTIC PARAMETERS IN ADVANCED EPITHELIAL OVARIAN-CARCINOMA - A PROSPECTIVE-STUDY

被引：31
作者：
KAERN, J
TROPE, CG
KRISTENSEN, GB
TVEIT, KM
PETTERSEN, EO
机构：
[1] NORWEGIAN RADIUM HOSP,DEPT MED ONCOL,OSLO,NORWAY
[2] NORWEGIAN RADIUM HOSP,INST CANC RES,DEPT TISSUE CULTURE,OSLO,NORWAY
来源：
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 1994年 / 170卷 / 02期
关键词：
PROSPECTIVE STUDY; ADVANCED OVARIAN CARCINOMA; DEOXYRIBONUCLEIC ACID PLOIDY; S-PHASE FRACTION; PROGNOSTIC FACTORS;
D O I：
10.1016/S0002-9378(94)70215-2
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
OBJECTIVE: Our goal was to study the prognostic value of deoxyribonucleic acid ploidy and S-phase fraction in advanced ovarian carcinoma. STUDY DESIGN: Prognostic factors for corrected survival were evaluated in a prospective study including 169 patients with stage III and IV ovarian cancer treated between 1985 and 1990. RESULTS: A total of 79% of the tumors were deoxyribonucleic acid aneuploid. Deoxyribonucleic acid aneuploidy was associated with grade of differentiation. S-phase fraction could be calculated in all deoxyribonucleic acid euploid tumors and 76% of the deoxyribonucleic acid aneuploid tumors. By multivariate analysis deoxyribonucleic acid ploidy, histologic type and grade, age, International Federation of Gynecology and Obstetrics stage, and amount of residual tumor were independent prognostic variables for corrected survival. On the basis of Cox regression a relative risk for the individual patient could be calculated. CONCLUSION: Deoxyribonucleic acid ploidy gives additive prognostic information and is a useful parameter for dividing patients with advanced ovarian cancer into risk groups for treatment decisions.
引用
收藏
页码：479 / 487
页数：9
相关论文
共 34 条
  • [1] BARNABEI VM, 1990, AM J OBSTET GYNECOL, V162, P1584
  • [2] TUMOR DNA CONTENT AS A PROGNOSTIC FEATURE IN ADVANCED EPITHELIAL OVARIAN-CARCINOMA
    BLUMENFELD, D
    BRALY, PS
    BENEZRA, J
    KLEVECZ, RR
    [J]. GYNECOLOGIC ONCOLOGY, 1987, 27 (03) : 389 - 402
  • [3] BRESCIA RJ, 1990, CANCER, V65, P141, DOI 10.1002/1097-0142(19900101)65:1<141::AID-CNCR2820650128>3.0.CO
  • [4] 2-I
  • [5] CHRISTOV K, 1987, CANCER, V60, P121
  • [6] COX DR, 1972, J R STAT SOC B, V34, P187
  • [7] MATHEMATICAL-ANALYSIS OF DNA DISTRIBUTIONS DERIVED FROM FLOW MICROFLUOROMETRY
    DEAN, PN
    JETT, JH
    [J]. JOURNAL OF CELL BIOLOGY, 1974, 60 (02) : 523 - 527
  • [8] CHOICE OF POSTOPERATIVE THERAPY BASED ON PROGNOSTIC FACTORS
    DEMBO, AJ
    BUSH, RS
    [J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1982, 8 (05): : 893 - 897
  • [9] FRIEDLANDER ML, 1984, CANCER RES, V44, P397
  • [10] PREDICTION OF LONG-TERM SURVIVAL BY FLOW CYTOMETRIC ANALYSIS OF CELLULAR DNA CONTENT IN PATIENTS WITH ADVANCED OVARIAN-CANCER
    FRIEDLANDER, ML
    HEDLEY, DW
    SWANSON, C
    RUSSELL, P
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 1988, 6 (02) : 282 - 290
1234