FURTHER-STUDIES OF THE MIXED ACETALS OF NUCLEOSIDES

被引：6

作者：

AUSTIN, J

DOSANJH, MK

FRAENKELCONRAT, H

机构：

[1] UNIV CALIF BERKELEY,DEPT MOLEC & CELL BIOL,229 STANLEY HALL,BERKELEY,CA 94720

[2] LAWRENCE BERKELEY LAB,DIV LIFE SCI,BERKELEY,CA 94720

来源：

BIOCHIMIE | 1993年 / 75卷 / 07期

关键词：

MUTAGENESIS; BENZYLALCOHOL; BUTYRALDEHYDE; PROPIOALDEHYDE;

D O I：

10.1016/0300-9084(93)90055-W

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We reported in 1988 on a new nucleoside modification reaction: the exocyclic amino groups of (d)adenosine and (d)cytidine react rapidly at ambient temperature with acetaldehyde and alcohols to give stable mixed acetals (N-ethylethoxy-acetal). [GRAPHICS] Here we report in detail on the occurrence of this reaction in very dilute aqueous solution (ie under biological conditions), on its mechanism and kinetics, on the mixed acetal formation with other aldehydes and other nucleic acid components, and on the question of whether these adducts are mutagenic.

引用

页码：511 / 515

页数：5

共 4 条

[1] TRYPTOPHAN ANALOGS FORM ADDUCTS BY COOPERATIVE REACTION WITH ALDEHYDES AND ALCOHOLS OR WITH ALDEHYDES ALONE - POSSIBLE ROLE IN ETHANOL TOXICITY [J].