FLUMAZENIL FOR THE REVERSAL OF REFRACTORY BENZODIAZEPINE-INDUCED SHOCK

被引:2
作者
COATES, W [1 ]
EVANS, TC [1 ]
JEHLE, D [1 ]
HARCHELROAD, F [1 ]
ISAACS, M [1 ]
机构
[1] ALLEGHENY GEN HOSP,DIV EMERGENCY MED,320 E N AVE,PITTSBURGH,PA 15212
来源
JOURNAL OF TOXICOLOGY-CLINICAL TOXICOLOGY | 1991年 / 29卷 / 04期
关键词
D O I
10.3109/15563659109025752
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
Benzodiazepines are known to cause central nervous system and centrally mediated cardiovascular depression. The benzodiazepine antagonist flumazenil has been shown to antagonize benzodiazepine-induced central nervous system depression. We report a case in which cardiovascular depression secondary to benzodiazepine use was reversed by this agent.
引用
收藏
页码:537 / 542
页数:6
相关论文
共 19 条
[11]  
GILLIS RA, 1984, FED PROC, V43, P32
[12]  
GOODMAN LS, 1985, PHARMACOL BASIS THER, P350
[13]   SELECTIVE ANTAGONISTS OF BENZODIAZEPINES [J].
HUNKELER, W ;
MOHLER, H ;
PIERI, L ;
POLC, P ;
BONETTI, EP ;
CUMIN, R ;
SCHAFFNER, R ;
HAEFELY, W .
NATURE, 1981, 290 (5806) :514-516
[14]   PHARMACOKINETICS OF THE SELECTIVE BENZODIAZEPINE ANTAGONIST RO 15-1788 IN MAN [J].
KLOTZ, U ;
ZIEGLER, G ;
REIMANN, IW .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1984, 27 (01) :115-117
[15]  
MARTINI C, 1986, GABAERGIC TRANSMISSI, P1
[16]  
MOEHLER H, 1981, Journal of Neurochemistry, V37, P714
[17]  
ORADELL NJ, 1990, PHYSICIANS DESK REFE, V44, P1827
[18]   VALUE OF FLUMAZENIL IN BENZODIAZEPINE SELF-POISONING [J].
PRISCHL, F ;
DONNER, A ;
GRIMM, G ;
SMETANA, R ;
HRUBY, K .
MEDICAL TOXICOLOGY AND ADVERSE DRUG EXPERIENCE, 1988, 3 (04) :334-339
[19]  
WILLETTE RN, 1984, J PHARMACOL EXP THER, V230, P34