BUTYLATED HYDROXYANISOLE INCREASES GLUTATHIONE-S-TRANSFERASE ACTIVITY IN HEPATOCYTE CULTURE

被引：0
作者：
CHEN, LH
机构：
来源：
ANTICANCER RESEARCH | 1990年 / 10卷 / 06期
关键词：
BHA; GLUTATHIONE-S-TRANSFERASE; 3-METHYLCHOLANTHRENE; HEPATOCYTE CULTURE;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The effect of butylated hydroxyanisole (BHA) on the activity of glutathione-S-transferase (GSH-S-T) in hepatocyte culture was determined. Hepatocytes from control rats and rats injected with 3-methylcholanthrene (3-MC) were isolated and cultured. The cultures were treated with various concentrations of BHA. Treatment of hepatocytes from both control and 3-MC-injected rats with 25-mu-M BHA for 24 or 48 hours increased GSH-S-T activity significantly. The results suggest that BHA may have a detoxifying effect against 3-MC-induced carcinogenesis, and that hepatocyte culture may be a fast and simple system to identify compounds which may potentially protect against development of cancer through induction of GSH-S-T.
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页码：1707 / 1710
页数：4
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