EFFECTS OF IONS ON THE BINDING OF AGONISTS AND ANTAGONISTS TO MUSCARINIC RECEPTORS

被引：74
作者：
BIRDSALL, NJM
BURGEN, ASV
HULME, EC
WELLS, JW
机构：
[1] Division of Molecular Pharmacology, National Institute for Medical Research, London
来源：
BRITISH JOURNAL OF PHARMACOLOGY | 1979年 / 67卷 / 03期
关键词：
D O I：
10.1111/j.1476-5381.1979.tb08690.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
There are no selective effects of Na+, K+, Ca2+, Mg2+ or Cl− on the binding of antagonists or agonists to muscarinic receptors in rat brain. A decrease in affinity related to ionic strength is found for all these ions. Larger effects were produced by T+, La3+, and some transition metal ions. 1979 British Pharmacological Society
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页码：371 / 377
页数：7
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