FAP-1 - A PROTEIN-TYROSINE-PHOSPHATASE THAT ASSOCIATES WITH FAS

被引：686

作者：

SATO, T ^{[1
]}

IRIE, S ^{[1
]}

KITADA, S ^{[1
]}

REED, JC ^{[1
]}

机构：

[1] LA JOLLA CANC RES FDN, ONCOGENE & TUMOR SUPPRESSOR GENE PROGRAM, LA JOLLA, CA 92037 USA

来源：

SCIENCE | 1995年 / 268卷 / 5209期

关键词：

D O I：

10.1126/science.7536343

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Fas is a cell surface receptor that controls a poorly understood signal transduction pathway that leads to cell death by means of apoptosis. A protein tyrosine phosphatase, FAP-1, capable of interacting with the cytosolic domain of Fas, was identified. The carboxyl terminal 15 amino acids of Fas are necessary and sufficient for interaction with FAP-1. FAP-1 expression is highest in tissues and cell lines that are relatively resistant to Fas-mediated cytotoxicity. Gene transfer-mediated elevations in FAP-1 partially abolished Fas-induced apoptosis in a T cell line. These findings are consistent with an inhibitory effect of FAP-1 on Fas signal transduction.

引用

页码：411 / 415

页数：5

共 25 条

[1] FAS TRANSDUCES ACTIVATION SIGNALS IN NORMAL HUMAN T-LYMPHOCYTES [J].

ALDERSON, MR ;

ARMITAGE, RJ ;

MARASKOVSKY, E ;

TOUGH, TW ;

ROUX, E ;

SCHOOLEY, K ;

RAMSDELL, F ;

LYNCH, DH .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (06) :2231-2235

[2] PROTECTION FROM FAS-MEDIATED APOPTOSIS BY A SOLUBLE FORM OF THE FAS MOLECULE [J].

CHENG, JH ;

ZHOU, T ;

LIU, CD ;

SHAPIRO, JP ;

BRAUER, MJ ;

KIEFER, MC ;

BARR, PJ ;

MOUNTZ, JD .

SCIENCE, 1994, 263 (5154) :1759-1762

[3]

EISCHEN CM, 1994, J IMMUNOL, V153, P1947

[4]

GORCZYCA W, 1993, CANCER RES, V53, P1945

[5]

ITOH N, 1993, J BIOL CHEM, V268, P10932

[6]

ITOH N, 1993, J IMMUNOL, V151, P621

[7] THE POLYPEPTIDE ENCODED BY THE CDNA FOR HUMAN CELL-SURFACE ANTIGEN FAS CAN MEDIATE APOPTOSIS [J].

ITOH, N ;

YONEHARA, S ;

ISHII, A ;

YONEHARA, M ;

MIZUSHIMA, S ;

SAMESHIMA, M ;

HASE, A ;

SETO, Y ;

NAGATA, S .

CELL, 1991, 66 (02) :233-243

[8] ACTIVATION INTERFERES WITH THE APO-1 PATHWAY IN MATURE HUMAN T-CELLS [J].

KLAS, C ;

DEBATIN, KM ;

JONKER, RR ;

KRAMMER, PH .

INTERNATIONAL IMMUNOLOGY, 1993, 5 (06) :625-630

[9] THE MOUSE FAS-LIGAND GENE IS MUTATED IN GLD MICE AND IS PART OF A TNF FAMILY GENE-CLUSTER [J].

LYNCH, DH ;

WATSON, ML ;

ALDERSON, MR ;

BAUM, PR ;

MILLER, RE ;

TOUGH, T ;

GIBSON, M ;

DAVISSMITH, T ;

SMITH, CA ;

HUNTER, K ;

BHAT, D ;

DIN, W ;

GOODWIN, RG ;

SELDIN, MF .

IMMUNITY, 1994, 1 (02) :131-136

[10] MOLECULAR-CLONING OF A NOVEL PROTEIN-TYROSINE-PHOSPHATASE CONTAINING A MEMBRANE-BINDING DOMAIN AND GLGF REPEATS [J].

MAEKAWA, K ;

IMAGAWA, N ;

NAGAMATSU, M ;

HARADA, S .

FEBS LETTERS, 1994, 337 (02) :200-206

← 1 2 3 →