BILATERAL SUBTHALAMIC NUCLEUS STIMULATION FOR SEVERE PARKINSONS-DISEASE

被引：225
作者：
LIMOUSIN, P
POLLAK, P
BENAZZOUZ, A
HOFFMANN, D
BROUSSOLLE, E
PERRET, JE
BENABID, AL
机构：
[1] UNIV GRENOBLE 1,DEPT CLIN & BIOL NEUROSCI,GRENOBLE,FRANCE
[2] HOP NEUROL,LYON,FRANCE
来源：
MOVEMENT DISORDERS | 1995年 / 10卷 / 05期
关键词：
SUBTHALAMIC NUCLEUS; STIMULATION; PARKINSONS DISEASE;
D O I：
10.1002/mds.870100523
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Subthalamic nucleus (STN) lesions or high-frequency stimulations could improve parkinsonian symptoms in monkeys treated by MPTP. We have applied the procedure of chronic stimulation to the STN in severely disabled parkinsonian patients. This article presents the case of the first patient operated on bilaterally. Bilateral STN stimulation has greatly improved akinesia and rigidity. The benefit was maintained less than or equal to 15 months after surgery. Unilateral stimulation induced motor effects mainly in contralateral limbs. Further studies are needed to evaluate the value of this procedure in the treatment of Parkinson's disease.
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页码：672 / 674
页数：3
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