CYTOKINES AND HIV-INFECTION

被引：7
作者：
SHEARER, GM [1 ]
CLERICI, M [1 ]
LUCEY, DR [1 ]
机构：
[1] UNIV MILAN,CATTEDRA IMMUNOL,I-20133 MILAN,ITALY
来源：
SEMINARS IN VIROLOGY | 1994年 / 5卷 / 06期
关键词：
AIDS CYTOKINES; HIV INFECTION; T HELPER CELLS; TYPE 1 VERSUS TYPE 2;
D O I：
10.1006/smvy.1994.1051
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Infection with the human immunodeficiency virus (HIV) results in the production of cytokines by cells that comprise the immune system. Such cytokines regulate both immune function and viral replication, and thereby complicate their contribution to the progression to AIDS. Certain cytokines that regulate immune function exert opposing effects, such that some promote mainly cellular immune function, whereas others enhance antibody production. It has been suggested that an imbalance in cytokine production is responsible ist part for the immune dysregulation characteristic of progression to AIDS. Different cytokines can also have different effects on HIV expression and replication. Cytokine-based therapy has been suggested for preventing or delaying progression to AIDS. If such therapy is to be successful, it will be necessary to identify the correlate of immune protection, as well as to determine which cytokines enhance or suppress protective immunity, and the effects of these cytokines on viral replication.
引用
收藏
页码：449 / 455
页数：7
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