A CELL-CYCLE-REGULATED INHIBITOR OF CYCLIN-DEPENDENT KINASES

被引：278

作者：

HENGST, L ^{[1
]}

DULIC, V ^{[1
]}

SLINGERLAND, JM ^{[1
]}

LEES, E ^{[1
]}

REED, SI ^{[1
]}

机构：

[1] MASSACHUSETTS GEN HOSP, CTR CANC, MOLEC ONCOL LAB, BOSTON, MA 02129 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1994年 / 91卷 / 12期

关键词：

D O I：

10.1073/pnas.91.12.5291

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cyclin-dependent kinases (Cdks) previously have been shown to drive the major cell cycle transitions in eukaryotic organisms ranging from yeast to humans. We report here the identification of a 28-kDa protein, p28(Ick) (inhibitor of cyclin-dependent kinase), that binds to and inhibits the kinase activity of preformed Cdk/cyclin complexes from human cells. p28 inhibitory activity fluctuates during the cell cycle with maximal levels in G(1) and accumulates in G(1)- and G(0)-arrested cells. These results suggest that control of the G(1)/S transition may be influenced by a family of Cdk inhibitors that include p28(Ick) and the recently described inhibitors p21(Cip1/Waf1/Cap20) and p16(Ink4).

引用

页码：5291 / 5295

页数：5

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