EXPRESSION CLONING OF AN EPITHELIAL AMILORIDE-SENSITIVE NA+ CHANNEL - A NEW CHANNEL TYPE WITH HOMOLOGIES TO CAENORHABDITIS-ELEGANS DEGENERINS

被引：327
作者：
LINGUEGLIA, E [1 ]
VOILLEY, N [1 ]
WALDMANN, R [1 ]
LAZDUNSKI, M [1 ]
BARBRY, P [1 ]
机构：
[1] INST PHARMACOL MOLEC & CELLULAIRE,660 ROUTE LUCIOLES,F-06560 VALBONNE,FRANCE
来源：
FEBS LETTERS | 1993年 / 318卷 / 01期
关键词：
SODIUM CHANNEL; AMILORIDE; EPITHELIA; COLON; NEURONAL DEGENERATION; CAENORHABDITIS-ELEGANS;
D O I：
10.1016/0014-5793(93)81336-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A complementary DNA encoding an amiloride-sensitive Na+ channel has been cloned and characterized from rat colon. The protein encoded by the cDNA has a sequence of 699 amino acids (79 kDa) containing several putative membrane spanning domains and potential phosphorylation sites. It forms a channel that has the electrophysiological and pharmacological properties characteristic of the epithelial Na+ channel. Homologies (including in transmembrane domains) have been found between a part of the channel sequence and the Mec4 gene product of Caenorhabditis elegans, a protein associated with mutation-induced neuronal degeneration.
引用
收藏
页码：95 / 99
页数：5
相关论文
共 35 条
  • [21] OSM-9 and an amiloride-sensitive channel, but not PKD-2, are involved in mechanosensation in C. elegans male ray neurons
    Zhang, Hu
    Yue, Xiaomin
    Cheng, Hankui
    Zhang, Xiaoyan
    Cai, Yang
    Zou, Wenjuan
    Huang, Guifang
    Cheng, Lufeng
    Ye, Fang
    Kang, Lijun
    SCIENTIFIC REPORTS, 2018, 8
  • [22] Low-amiloride-affinity Na+ channel in the epithelial cells isolated from the endolymphatic sac of guinea-pigs
    Mori, N
    Wu, DZ
    PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1996, 433 (1-2): : 58 - 64
  • [23] New insights regarding epithelial Na+ channel regulation and its role in the kidney, immune system and vasculature
    Mutchler, Stephanie M.
    Kleyman, Thomas R.
    CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION, 2019, 28 (02) : 113 - 119
  • [24] Bradykinin acutely inhibits activity of the epithelial Na+ channel in mammalian aldosterone-sensitive distal nephron
    Zaika, Oleg
    Mamenko, Mykola
    O'Neil, Roger G.
    Pochynyuk, Oleh
    AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2011, 300 (05) : F1105 - F1115
  • [25] Modulation of Na+ transport and epithelial sodium channel expression by protein kinase C in rat alveolar epithelial cells
    Yamagata, T
    Yamagata, Y
    Massé, C
    Tessier, MC
    Brochiero, E
    Dagenais, A
    Berthiaume, Y
    CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2005, 83 (11) : 977 - 987
  • [26] N-linked glycans are required on epithelial Na+ channel subunits for maturation and surface expression
    Kashlan, Ossama B.
    Kinlough, Carol L.
    Myerburg, Michael M.
    Shi, Shujie
    Chen, Jingxin
    Blobner, Brandon M.
    Buck, Teresa M.
    Brodsky, Jeffrey L.
    Hughey, Rebecca P.
    Kleyman, Thomas R.
    AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2018, 314 (03) : F483 - F492
  • [27] Liddle's syndrome mutations increase Na+ transport through dual effects on epithelial Na+ channel surface expression and proteolytic cleavage
    Knight, KK
    Olson, DR
    Zhou, RF
    Snyder, PM
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (08) : 2805 - 2808
  • [28] Heme oxygenase-1 promotes migration and β-epithelial Na+ channel expression in cytotrophoblasts and ischemic placentas
    Warrington, Junie P.
    Coleman, Kayla
    Skaggs, Courtney
    Hosick, Peter A.
    George, Eric M.
    Stec, David E.
    Ryan, Michael J.
    Granger, Joey P.
    Drummond, Heather A.
    AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2014, 306 (09) : R641 - R646
  • [29] Flow-sensitive K+-coupled ATP Secretion Modulates Activity of the Epithelial Na+ Channel in the Distal Nephron
    Bugaj, Vladislav
    Sansom, Steven C.
    Wen, Donghai
    Hatcher, Lori I.
    Stockand, James D.
    Mironova, Elena
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (46) : 38552 - 38558
  • [30] Identification and expression of the Na+/H+ exchanger in mammalian cerebrovascular and choroidal tissues:: Characterization by amiloride-sensitive [3H]MIA binding and RT-PCR analysis
    Kalaria, RN
    Premkumar, DRD
    Lin, CW
    Kroon, SN
    Bae, JY
    Sayre, LM
    LaManna, JC
    MOLECULAR BRAIN RESEARCH, 1998, 58 (1-2): : 178 - 187
1234