EXPRESSION CLONING OF AN EPITHELIAL AMILORIDE-SENSITIVE NA+ CHANNEL - A NEW CHANNEL TYPE WITH HOMOLOGIES TO CAENORHABDITIS-ELEGANS DEGENERINS

被引：329

作者：

LINGUEGLIA, E ^{[1
]}

VOILLEY, N ^{[1
]}

WALDMANN, R ^{[1
]}

LAZDUNSKI, M ^{[1
]}

BARBRY, P ^{[1
]}

机构：

[1] INST PHARMACOL MOLEC & CELLULAIRE,660 ROUTE LUCIOLES,F-06560 VALBONNE,FRANCE

来源：

FEBS LETTERS | 1993年 / 318卷 / 01期

关键词：

SODIUM CHANNEL; AMILORIDE; EPITHELIA; COLON; NEURONAL DEGENERATION; CAENORHABDITIS-ELEGANS;

D O I：

10.1016/0014-5793(93)81336-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A complementary DNA encoding an amiloride-sensitive Na+ channel has been cloned and characterized from rat colon. The protein encoded by the cDNA has a sequence of 699 amino acids (79 kDa) containing several putative membrane spanning domains and potential phosphorylation sites. It forms a channel that has the electrophysiological and pharmacological properties characteristic of the epithelial Na+ channel. Homologies (including in transmembrane domains) have been found between a part of the channel sequence and the Mec4 gene product of Caenorhabditis elegans, a protein associated with mutation-induced neuronal degeneration.

引用

页码：95 / 99

页数：5

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