2-HYDROXYPROPYL-BETA-CYCLODEXTRIN COMPLEXATION WITH URSODEOXYCHOLIC ACID

被引：58
|
作者：
VANDELLI, MA
SALVIOLI, G
MUCCI, A
PANINI, R
MALMUSI, L
FORNI, F
机构：
[1] UNIV MODENA, DEPT PHARMACEUT SCI, I-41100 MODENA, ITALY
[2] UNIV MODENA, CATTEDRA GERIATR & GERONTOL, I-41100 MODENA, ITALY
[3] UNIV MODENA, DEPT CHEM, I-41100 MODENA, ITALY
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1995年 / 118卷 / 01期
关键词：
URSODEOXYCHOLIC ACID; 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN; INCLUSION COMPLEXATION; SOLUBILITY STUDY; SOLID-PHASE STUDY; DRUG DISSOLUTION;
D O I：
10.1016/0378-5173(94)00342-3
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The complexation in aqueous medium and in the solid phase of ursodeoxycholic acid (UDCA) with a highly soluble cyclodextrin, 2-hydroxypropyl-beta-cyclodextrin, was studied by means of solubility methods, IR and C-13-NMR spectroscopy, X-ray diffractometry and thermal analysis. UDCA inclusion took place with 1:1 stoichiometry. C-13-NMR analysis suggested that the side chain was introduced into the cyclodextrin cavity. The UDCA/cyclodextrin complex showed better dissolution properties than plain drug crystals. Therefore, the complex may be used to improve the delivery and bioavailability of ursodeoxycholic acid.
引用
收藏
页码：77 / 83
页数：7
相关论文
共 50 条
  • [1] IMPROVEMENT OF URSODEOXYCHOLIC ACID BIOAVAILABILITY BY 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN COMPLEXATION IN HEALTHY-VOLUNTEERS
    PANINI, R
    VANDELLI, MA
    FORNI, F
    PRADELLI, JM
    SALVIOLI, G
    PHARMACOLOGICAL RESEARCH, 1995, 31 (3-4) : 205 - 209
  • [2] COMPLEXATION OF VARIOUS FRAGRANCE MATERIALS WITH 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN
    MATSUDA, H
    ITO, K
    FUJIWARA, Y
    TANAKA, M
    TAKI, A
    UEJIMA, O
    SUMIYOSHI, H
    CHEMICAL & PHARMACEUTICAL BULLETIN, 1991, 39 (04) : 827 - 830
  • [3] COMPLEXATION OF DIHYDROPYRIDINE DERIVATIVES WITH CYCLODEXTRINS AND 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN IN SOLUTION
    MULLER, BW
    ALBERS, E
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1992, 79 (2-3) : 273 - 288
  • [4] BILE-ACID AND STEROL SOLUBILIZATION IN 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN
    DECAPRIO, J
    YUN, J
    JAVITT, NB
    JOURNAL OF LIPID RESEARCH, 1992, 33 (03) : 441 - 443
  • [5] INCLUSION COMPLEXATION OF GLIBENCLAMIDE WITH 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN IN SOLUTION AND IN SOLID-STATE
    ESCLUSADIAZ, MT
    TORRESLABANDEIRA, JJ
    KATA, M
    VILAJATO, JL
    EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 1994, 1 (06) : 291 - 296
  • [6] SOLUBILIZATION OF THIAZOLOBENZIMIDAZOLE USING A COMBINATION OF PH ADJUSTMENT AND COMPLEXATION WITH 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN
    TINWALLA, AY
    HOESTEREY, BL
    XIANG, TX
    LIM, K
    ANDERSON, BD
    PHARMACEUTICAL RESEARCH, 1993, 10 (08) : 1136 - 1143
  • [7] MICROCALORIMETRIC INVESTIGATION OF THE COMPLEXATION BETWEEN 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN AND AMINE DRUGS WITH THE DIPHENYLMETHYL FUNCTIONALITY
    TONG, WQ
    LACH, JL
    CHIN, TF
    GUILLORY, JK
    JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1991, 9 (10-12) : 1139 - 1146
  • [8] Multiple modes for inclusion complexation between phenobarbital and 2-hydroxypropyl-beta-cyclodextrin in aqueous solution
    Aki, H
    Haraguchi, T
    Niiya, T
    Goto, Y
    Yamamoto, M
    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 1996, 116 (10): : 803 - 812
  • [9] INTERACTIONS BETWEEN PRESERVATIVES AND 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN
    LOFTSSON, T
    STEFANSDOTTIR, O
    FRIORIKSDOTTIR, H
    GUOMUNDSSON, O
    DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1992, 18 (13) : 1477 - 1484
  • [10] Complexation of bile acids with 2-hydroxypropyl-beta-cyclodextrin: A C-13-NMR study
    Mucci, A
    Vandelli, MA
    Salvioli, G
    Malmusi, L
    Forni, F
    Schenetti, L
    SUPRAMOLECULAR CHEMISTRY, 1996, 7 (02) : 125 - 127
12345