LEAD EFFECT ON THE OXIDATION RESISTANCE OF ERYTHROCYTE-MEMBRANE IN RAT TRITON-INDUCED HYPERLIPIDEMIA

被引：14
|
作者：
ZIMMERMANN, L [1 ]
PAGES, N [1 ]
ANTEBI, H [1 ]
HAFI, A [1 ]
BOUDENE, C [1 ]
ALCINDOR, LG [1 ]
机构：
[1] FAC PHARM CHATENAY MALABRY, TOXICOL LAB, F-92296 CHATENAY MALABRY, FRANCE
来源：
BIOLOGICAL TRACE ELEMENT RESEARCH | 1993年 / 38卷 / 03期
关键词：
TRITON-INDUCED HYPERLIPIDEMIA; LEAD-TREATED RAT; ERYTHROCYTE MEMBRANE; LIPID PEROXIDATION;
D O I：
10.1007/BF02785314
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The anemia observed in severe chronic lead poisoning is in part attributable to alterations in the erythrocyte physicochemical properties. Since they are partly related to the membrane lipid composition, the aim of the present study was to determine the effects of a triton-induced hyperlipidemia on the resistance to oxidation of erythrocyte membranes in lead-treated Wistar rats. Our results showed that triton administration to lead-treated rats induced an increase in erythrocyte choline phospholipid levels together with a significant decrease in the erythrocyte membrane lipid resistance to oxidation. These results led us to suggest that anemia in lead poisoning is linked to interactions between lead present in the membrane and plasma phospholipids. Their increase in rat hyperlipidemia induced by triton resulted in a decrease in the membrane resistance to oxidation and finally in an erythrocyte fragility leading to their destruction.
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页码：311 / 318
页数：8
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