COULD NON-INSULIN-DEPENDENT DIABETES-MELLITUS BE ATTRIBUTABLE TO A DEFICIENCY OF FAD-LINKED GLYCEROPHOSPHATE DEHYDROGENASE

被引：14
作者：
MALAISSE, WJ [1 ]
MALAISSELAGAE, F [1 ]
KUKEL, S [1 ]
REINHOLD, U [1 ]
SENER, A [1 ]
机构：
[1] UNIV BONN,DEPT DERMATOL,W-5300 BONN,GERMANY
来源：
BIOCHEMICAL MEDICINE AND METABOLIC BIOLOGY | 1993年 / 50卷 / 02期
关键词：
D O I：
10.1006/bmmb.1993.1064
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In 12 out of 32 non-insulin-dependent diabetic subjects, the activity of FAD-linked glycerophosphate dehydrogenase in T lymphocyte homogenates was abnormally low when measured by both a colonimetric and radioisotopic procedure. A comparable situation characterized by a deficient activity of FAD-linked glycerophosphate dehydrogenase in both the colonimetric and radioisotopic assays was only observed once among 26 other subjects including 11 healthy volunteers, 9 non-diabetic patients, 5 type-1 (insulin-dependent) diabetics, and 1 pancreatectomized diabetic. By analogy, it is speculated that an impaired activity of FAD-linked glycerophosphate dehydrogenase in the insulin-producing pancreatic B-cell could represent a far-from-uncommon contributive factor in the pathogenesis of non-insulin-dependent diabetes mellitus. © 1993 Academic Press. All rights reserved.
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页码：226 / 232
页数：7
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