PREPARATION OF NUCLEOTIDE MIMICS WITH POTENT INHIBITORY ACTIVITY AGAINST HIV REVERSE-TRANSCRIPTASE

被引：18

作者：

COE, DM

ORR, DC

ROBERTS, SM

STORER, R

机构：

[1] GLAXO GRP RES LTD,GREENFORD UB6 0HE,MIDDX,ENGLAND

[2] GLAXO GRP RES LTD,DEPT MED CHEM,GREENFORD UB6 0HE,MIDDX,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1991年 / 12期

关键词：

D O I：

10.1039/p19910003378

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The triphosphate 11 has been synthesised in eight steps from 6-oxabicyclo[3.1.0]hex-2-ene 6 and has been shown to inhibit the enzyme, human immunodeficiency virus reverse transcriptase (HIV-rt).

引用

页码：3378 / 3379

页数：2

共 7 条

[1]

COE D, 1989, CHEM IND-LONDON, P724

[2] SYNTHESIS OF COMPOUNDS ACTIVE AGAINST HIV .2. PREPARATION OF SOME 2',3'-DIDEOXY-6'-FLUOROCARBOCYCLIC NUCLEOSIDES [J].

COE, DM ;

MYERS, PL ;

PARRY, DM ;

ROBERTS, SM ;

STORER, R .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1990, (02) :151-153

[3] SYNTHESIS OF SOME MIMICS OF NUCLEOSIDE TRIPHOSPHATES [J].

COE, DM ;

HILPERT, H ;

NOBLE, SA ;

PEEL, MR ;

ROBERTS, SM ;

STORER, R .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1991, (05) :312-314

[4]

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[5]

Korach M., 1973, ORG SYN COLL, VV, P414

[6]

ROBERTS SM, 1991, CHEM BRIT, P518

[7]

TYALOR SJC, 1990, J CHEM SOC CHEM COMM, P1120

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