CORRELATION BETWEEN STRUCTURE AND GAS-CHROMATOGRAPHIC BEHAVIOR OF NITROGEN-CONTAINING HETEROCYCLIC-COMPOUNDS .2. ALKYL SUBSTITUTION OF QUINAZOLONE DERIVATIVES

Mono- and dialkyl-substituted quinazolones were synthesized by literature or its modifications. Six homologous series were prepared, varying in the substituent introduced and its position. The retention indices of the compounds were determined on OV-1 and OV-25 stationary phases. The influence of the number of carbon atoms in the homologues alkyl chain on the I and DELTA-I values could be characterized well. The behaviour of the alkylquinazolones and the ring-closed tricyclic with the same number of carbon atoms could also be characterized numerically. A dominant effect was exerted by the substituent in the neighbouring position to the alkyl chain.