ENDODERMAL GERM-CELL CARCINOMA (ENDODERMAL SINUS TUMOR) OF THE VAGINA IN INFANT GIRLS

被引:28
作者
BELLER, FK
NIENHAUS, H
SCHMUNDTVONGIZYCKI, B
SCHELLONG, G
BUNTE, H
SCHMANDT, W
机构
[1] ONCOL WORKING GRP MUNSTER,DEPT OBSTET & GYNECOL,MUNSTER,FED REP GER
[2] ONCOL WORKING GRP MUNSTER,DEPT GYNECOPATHOL,GYNECOL CLIN,MUNSTER,FED REP GER
[3] ONCOL WORKING GRP MUNSTER,INST PATHOL,MUNSTER,FED REP GER
[4] ONCOL WORKING GRP MUNSTER,PEDIAT CLIN,DEPT HEMATOL,MUNSTER,FED REP GER
[5] UNIV MUNSTER,DEPT GEN SURG,D-4400 MUNSTER,FED REP GER
[6] UNIV MUNSTER,SURG CLIN,DEPT UROL,D-4400 MUNSTER,FED REP GER
关键词
Endodermal sinus tumor; Pathology; Therapy;
D O I
10.1007/BF00419289
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
An endodermal sinus tumor (endodermal germ cell carcinoma) was diagnosed in a 1-year-old girl in the vagina after vaginal hemorrhage; the tumor was completely removed by radical abdominal surgery. Postoperative polychemotherapy was performed for two years with Actinomycin D, Adriamycin, Vincristin, and Cyclophosphamide. The infant is now tumor-free for 26 months, showing almost normal somatic and psychic development. The characteristic histological patterns and clinical course of this strongly malignant tumor are demonstrated, based on 25 published casereports of endodermal sinus tumors in the vagina of little girls (aged 5-26 months). This neoplasm in early infancy has to be separated from the clear-cell adenocarcinoma of the vagina which occurs after puberty in adolescent girls and young women, and is induced by stilbestrol therapy to the mother during early pregnancy. © 1979 Springer-Verlag.
引用
收藏
页码:295 / 306
页数:12
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