RE-RANKING FOR PRIORITIZATION OF DISEASE-RELATED GENES

被引：0
作者：
Gong, Lejun [1 ]
Yang, Ronggen [2 ]
Zhang, Chun [1 ]
Liu, Quan [1 ]
Lee, Huakang [1 ]
Yang, Geng [1 ]
机构：
[1] Nanjing Univ Posts & Telecommun, Coll Comp Sci & Technol, Jiangsu High Technol Res Key Lab Wireless Sensor, Nanjing 210003, Jiangsu, Peoples R China
[2] Jinling Inst Technol, Fac Informat Technol, Nanjing 211169, Jiangsu, Peoples R China
来源：
BIOMEDICAL ENGINEERING-APPLICATIONS BASIS COMMUNICATIONS | 2016年 / 28卷 / 04期
基金：
中国博士后科学基金; 中国国家自然科学基金;
关键词：
Association rules; Text mining; Gene prioritization; Disease-related genes;
D O I：
10.4015/S1016237216500277
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
To explore the genetic complexity of disease, this paper focuses on the prioritization of susceptibility genes by re-ranking. This approach prioritizes disease-related genes based on the prior ranking. The genes in prior ranking are divided into seeds and candidates. And then these seed genes are used to prioritize candidates based on association rules. Experimental results show the approach is promising for finding new disease-related genes.
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页数：8
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