Mental Health Comorbidities in Pediatric Chronic Pain: A Narrative Review of Epidemiology, Models, Neurobiological Mechanisms and Treatment

被引:128
作者
Vinall, Jillian [1 ]
Pavlova, Maria [2 ]
Asmundson, Gordon J. G. [3 ]
Rasic, Nivez [1 ]
Noel, Melanie [2 ,4 ]
机构
[1] Univ Calgary, Dept Anesthesia, Calgary, AB T3B 6A8, Canada
[2] Univ Calgary, Dept Psychol, Calgary, AB T2N 1N4, Canada
[3] Univ Regina, Dept Psychol, Regina, SK S4S 0A2, Canada
[4] Alberta Childrens Prov Gen Hosp, Div Behaviour & Developing Brain, Res Inst, Calgary, AB T3B 6A8, Canada
来源
CHILDREN-BASEL | 2016年 / 3卷 / 04期
基金
加拿大健康研究院;
关键词
chronic pain; posttraumatic stress disorder; anxiety; depression; neurobiology; stress; brain; comorbidity; parent; intervention;
D O I
10.3390/children3040040
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Chronic pain during childhood and adolescence can lead to persistent pain problems and mental health disorders into adulthood. Posttraumatic stress disorders and depressive and anxiety disorders are mental health conditions that co-occur at high rates in both adolescent and adult samples, and are linked to heightened impairment and disability. Comorbid chronic pain and psychopathology has been explained by the presence of shared neurobiology and mutually maintaining cognitive-affective and behavioral factors that lead to the development and/or maintenance of both conditions. Particularly within the pediatric chronic pain population, these factors are embedded within the broader context of the parent-child relationship. In this review, we will explore the epidemiology of, and current working models explaining, these comorbidities. Particular emphasis will be made on shared neurobiological mechanisms, given that the majority of previous research to date has centered on cognitive, affective, and behavioral mechanisms. Parental contributions to co-occurring chronic pain and psychopathology in childhood and adolescence will be discussed. Moreover, we will review current treatment recommendations and future directions for both research and practice. We argue that the integration of biological and behavioral approaches will be critical to sufficiently address why these comorbidities exist and how they can best be targeted in treatment.
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页数:31
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共 211 条
  • [1] SUBTYPE-SPECIFIC CHANGES IN 5-HT RECEPTOR-MEDIATED MODULATION OF C FIBRE-EVOKED SPINAL FIELD POTENTIALS ARE TRIGGERED BY PERIPHERAL NERVE INJURY
    Aira, Z.
    Buesa, I.
    Salgueiro, M.
    Bilbao, J.
    Aguilera, L.
    Zimmermann, M.
    Azkue, J. J.
    [J]. NEUROSCIENCE, 2010, 168 (03) : 831 - 841
  • [2] A Unified, Transdiagnostic Treatment for Adolescents With Chronic Pain and Comorbid Anxiety and Depression
    Allen, Laura B.
    Tsao, Jennie C. I.
    Seidman, Laura C.
    Ehrenreich-May, Jill
    Zeltzer, Lonnie K.
    [J]. COGNITIVE AND BEHAVIORAL PRACTICE, 2012, 19 (01) : 56 - 67
  • [3] Cross-sex hormone administration changes pain in transsexual women and men
    Aloisi, Anna Maria
    Bachiocco, Valeria
    Costantino, Antonletta
    Stefani, Rita
    Ceccarelli, Ilaria
    Bertaccini, Alessandro
    Meriggiola, Maria Cristina
    [J]. PAIN, 2007, 132 : S60 - S67
  • [4] Human brain mechanisms of pain perception and regulation in health and disease
    Apkarian, AV
    Bushnell, MC
    Treede, RD
    Zubieta, JK
    [J]. EUROPEAN JOURNAL OF PAIN, 2005, 9 (04) : 463 - 484
  • [5] PTSD and the experience of pain: Research and clinical implications of shared vulnerability and mutual maintenance models
    Asmundson, GJG
    Coons, MJ
    Taylor, S
    Katz, J
    [J]. CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE, 2002, 47 (10): : 930 - 937
  • [6] THE EMOTIONAL AND PHYSICAL PAINS OF TRAUMA: CONTEMPORARY AND INNOVATIVE APPROACHES FOR TREATING CO-OCCURRING PTSD AND CHRONIC PAIN
    Asmundson, Gordon J. G.
    [J]. DEPRESSION AND ANXIETY, 2014, 31 (09) : 717 - 720
  • [7] UNDERSTANDING THE CO-OCCURRENCE OF ANXIETY DISORDERS AND CHRONIC PAIN: STATE-OF-THE-ART
    Asmundson, Gordon J. G.
    Katz, Joel
    [J]. DEPRESSION AND ANXIETY, 2009, 26 (10) : 888 - 901
  • [8] Brain mediators of the effects of noxious heat on pain
    Atlas, Lauren Y.
    Lindquist, Martin A.
    Bolger, Niall
    Wager, Tor D.
    [J]. PAIN, 2014, 155 (08) : 1632 - 1648
  • [9] Corticostriatal functional connectivity predicts transition to chronic back pain
    Baliki, Marwan N.
    Petre, Bogdan
    Torbey, Souraya
    Herrmann, Kristina M.
    Huang, Lejian
    Schnitzer, Thomas J.
    Fields, Howard L.
    Apkarian, A. Vania
    [J]. NATURE NEUROSCIENCE, 2012, 15 (08) : 1117 - +
  • [10] Psychopathological symptoms in child and adolescent migraine and tension-type headache: A meta-analysis
    Balottin, Umberto
    Poli, Paolo Fusar
    Termine, Cristiano
    Molteni, Silvia
    Galli, Federica
    [J]. CEPHALALGIA, 2013, 33 (02) : 112 - 122