DECREASE IN ASPARAGINE SYNTHETASE-ACTIVITY DURING CELL-DIFFERENTIATION OF MOUSE AND HUMAN LEUKEMIA-CELL LINES

被引：0
作者：
HONGO, S [1 ]
SAKAGAMI, H [1 ]
SATO, T [1 ]
机构：
[1] SHOWA UNIV,SCH MED,DEPT BIOCHEM 1,TOKYO 142,JAPAN
来源：
LEUKEMIA | 1990年 / 4卷 / 10期
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D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The activity of asparagine synthetase decreased almost 50% during dexamethasone-induced mouse myeloid leukemia M1 cell differentiation. This enzyme activity also declined significantly during differentiation of the human myelogenous leukemic cell lines, HL-60 and U-937, induced by either macrophage culture supernatant or retinoic acid. The decline of asparagine synthetase activity closely paralleled the expression of various maturation markers, but could also be induced by serum starvation. These results suggest that asparagine synthetase or L-asparagine has some biological function in growth regulation of these leukemia cell lines.
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页码：708 / 711
页数：4
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