FIBER OPTIC EVANESCENT WAVE IMMUNOSENSORS FOR MEDICAL DIAGNOSTICS

被引：52
作者：
BLUESTEIN, BI
WALCZAK, IM
CHEN, SY
机构：
[1] Research and Development Group, Ciba-Corning Diagnostics Corporation, Medfield, MA 02052
来源：
TRENDS IN BIOTECHNOLOGY | 1990年 / 8卷 / 06期
关键词：
D O I：
10.1016/0167-7799(90)90163-R
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Immunodiagnostic sensors permit sensitive measurement of a wide variety of both high and low molecular mass analytes - serum analytes may be detected at picomolar concentrations. Due to the sensor monitoring antigen-antibody reactions directly, quantitative results are available within seconds to minutes of sample introduction. In recent years, the trend has been for immunodiagnostics to be used at sites away from centralized medical laboratories. Specific requirements associated with such use are being achieved by the development of optical devices incorporating evanescent wave sensors. © 1990.
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页码：161 / 168
页数：8
相关论文
共 50 条
[1]  
ANDERSON FP, 1988, CLIN CHEM, V34, P1417
[2]  
ANDRADE JD, 1983, Patent No. 4368047
[3]  
ANGEL SM, 1987, SPECTROSCOPY, V2, P34
[4]  
[Anonymous], 1986, US Pat, Patent No. [4608344, 4,608,344]
[5]  
APPLE FS, 1987, CLIN CHEM, V33, P507
[6]  
AVRAMEAS S, 1981, IMMUNOASSAYS 80S, P85
[7]   TOTAL INTERNAL-REFLECTION FLUORESCENCE [J].
AXELROD, D ;
BURGHARDT, TP ;
THOMPSON, NL .
ANNUAL REVIEW OF BIOPHYSICS AND BIOENGINEERING, 1984, 13 :247-268
[8]   OPTICAL BIOSENSORS FOR IMMUNOASSAYS - THE FLUORESCENCE CAPILLARY-FILL DEVICE [J].
BADLEY, RA ;
DRAKE, RAL ;
SHANKS, IA ;
SMITH, AM ;
STEPHENSON, PR ;
THOMAS, JDR .
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, 1987, 316 (1176) :143-160
[9]  
BLOCK MJ, 1988, CRDECTR88071 US ARM
[10]  
BLOCK MJ, 1986, Patent No. 4582809
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