SYNTHESIS OF SOME NEW 2-(N-SUBSTITUTED)- 3H- PHTHALAZIN- 1, 4- DIONE DERIVATIVES FOR THEIR ANTIHYPERTENSIVE ACTIVITY

被引：0
|
作者：
Namdeo, Kamta P. [1 ]
Jaiswal, Shilpa [1 ]
机构：
[1] Guru Ghasidas Vishwavidyalaya, SLT Inst Pharmaceut Sci, Bilaspur 495009, Chhattisgarh, India
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH | 2018年 / 9卷 / 09期
关键词：
Anti-hypertensive; Pthalazinedione; Hypotensive; Phthalazin-1; 4-Dione;
D O I：
10.13040/IJPSR.0975-8232.9(9).3999-07
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Present study is reporting the results of the synthesis and evaluation of antihypertensive activity for 2-N-substituted pthalazine 1,4-dione derivatives. 2-N-substituted pthalazine 1,4-dione derivatives were synthesized by taking the Heterocyclic system, ethylglycinate, hydrazine hydrate and pthalic anhydride and were subjected to preliminary screening for antihypertensive activity in albino rats. The synthesized compounds were characterized on the basis of their spectral (H-1 NMR, C-13 NMR, Mass, IR) analysis. Antihypertensive activity of all the compounds were tested by non-invasive method using Tail Cuff method and all the compounds were found to be active. The significance of the work is to treat cardiovascular disorder particular hypertension.
引用
收藏
页码：3999 / 4007
页数：9
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