EFFECTS OF KN-62, A SPECIFIC INHIBITOR OF CALCIUM CALMODULIN-DEPENDENT PROTEIN KINASE-II, ON LONG-TERM POTENTIATION IN THE RAT HIPPOCAMPUS

被引：112

作者：

ITO, I

HIDAKA, H

SUGIYAMA, H

机构：

[1] NAGOYA UNIV,SCH MED,DEPT PHARMACOL,NAGOYA,AICHI 466,JAPAN

[2] CHGAI PHARMACEUT CO,FUJIGOTEMBA RES LABS,GOTEMBA,JAPAN

[3] NATL INST PHYSIOL SCI,DEPT CELLULAR PHYSIOL,OKAZAKI,AICHI 444,JAPAN

来源：

NEUROSCIENCE LETTERS | 1991年 / 121卷 / 1-2期

关键词：

LONG-TERM POTENTIATION; CALMODULIN; PROTEIN KINASE; HIPPOCAMPUS;

D O I：

10.1016/0304-3940(91)90663-E

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Effects of KN-62 (1-[NO-bis-1,5-isoquinolinesulfonyl]-N-methyl-L-tyrosyl-4-phenylpiperazine), a specific inhibitor of calcium/calmodulin-dependent protein kinase II, were examined using rat hippocampus slices in vitro. The inhibitor, when applied in bathing solutions prior to and present during the tetanic stimulations, blocked the generation of long-term potentiation (LTP) in CA1 regions without affecting basal synaptic transmission itself, suggesting an important role of this kinase in the molecular mechanism of CA1 LTP. In contrast, mossy fiber LTP in CA3 regions was not affected significantly by the inhibitor.

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页码：119 / 121

页数：3

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