BAKERS-YEAST, THE NEW-YORK HORSE IN PROTEIN-SYNTHESIS STUDIES - ANALYZING EUKARYOTIC TRANSLATION INITIATION

被引：29
作者：
LINDER, P
PRAT, A
机构：
[1] Department of Microbiology, Basel, CH-4056, Klingelbergstr
来源：
BIOESSAYS | 1990年 / 12卷 / 11期
关键词：
D O I：
10.1002/bies.950121103
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The possibility of combining powerful genetic methods with biochemical analysis has made baker's yeast Saccharomyces cerevisiae the organism of choice to study the complex process of translation initiation in eukaryotes. Several new initiation factor genes and interactions between components of the translational machinery that were not predicted by current models have been revealed by genetic analysis of extragenic suppressors of translational initiation mutants. In addition, a yeast cell‐free translation system has been developed that allows in vivo phenotypes to be correlated with in vitro biochemical activities. We summarize here the current view of yeast translational initiation obtained by these approaches. Copyright © 1990 Cambridge University Press
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页码：519 / 526
页数：8
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