ACTIVATION OF THE GLYCINE SITE IN THE NMDA RECEPTOR IS NECESSARY FOR THE INDUCTION OF LTP

被引：78
作者：
BASHIR, ZI
TAM, B
COLLINGRIDGE, GL
机构：
[1] Department of Pharmacology, School of Medical Sciences, University of Bristol, Bristol
来源：
NEUROSCIENCE LETTERS | 1990年 / 108卷 / 03期
关键词：
7-Chlorokynurenate; Allosteric glycine site; d-Serine; Hippocampus; Long-term potentiation; N-Methyl-d-aspartate receptor;
D O I：
10.1016/0304-3940(90)90651-O
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The effects of 7-chlorokynurenate (7-C1KY) were examined on N-methyl-d-aspartate (NMDA) receptor-mediated synaptic mechanisms in the CA1 region of rat hippocampal slices. 7-C1KY depressed both the NMDA receptor-mediated component of synaptic transmission recorded in Mg2+-free medium and the induction of long-term potentiation (LTP) in Mg2+-containing medium. Both of these effects were reversed by d-serine, suggesting that the action of 7-C1KY was at the allosteric glycine site on the NMDA receptor. © 1990.
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页码：261 / 266
页数：6
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