Venous thromboembolism in cancer patients: risk assessment, prevention and management

被引:2
作者
Tukaye, Deepali N. [1 ]
Brink, Heidi [2 ]
Baliga, Ragavendra [1 ]
机构
[1] Ohio State Univ, Dept Med, Div Cardiovasc Med, 473 W 12th Ave,200, Columbus, OH 43210 USA
[2] Ohio State Univ, Coll Pharm, 500 W 12th Ave,217, Columbus, OH 43210 USA
关键词
guidelines-based VTE management; risk stratification; thrombosis in cancer patients; VTE prevention;
D O I
10.2217/fca.15.87
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Thrombosis and thromboembolic events contribute to significant morbidity in cancer patients. Venous thrombosis embolism (which includes deep vein thrombosis and pulmonary embolism) accounts for a large percentage of thromboembolic events. Appropriate identification of cancer patients at high risk for venous thromboembolism and management of thromboembolic event is crucial in improving the quality of care for cancer patients. However, thromboembolism in cancer patients is a complex problem and the management has to be tailored to each individual. The focus of this review is to understand the complex pathology, physiology and risk factors that drive the process of venous thrombosis and embolism in cancer patients and the current guidelines in management.
引用
收藏
页码:221 / 235
页数:15
相关论文
共 129 条
[91]   Post-Discharge Venous Thromboembolism After Cancer Surgery Extending the Case for Extended Prophylaxis [J].
Merkow, Ryan P. ;
Bilimoria, Karl Y. ;
McCarter, Martin D. ;
Cohen, Mark E. ;
Barnett, Carlton C. ;
Raval, Mehul V. ;
Caprini, Joseph A. ;
Gordon, Howard S. ;
Ko, Clifford Y. ;
Bentrem, David J. .
ANNALS OF SURGERY, 2011, 254 (01) :131-137
[92]   Comparison of low-molecular-weight heparin and warfarin for the secondary prevention of venous thromboembolism in patients with cancer - A randomized controlled study [J].
Meyer, G ;
Marjanovic, Z ;
Valcke, J ;
Lorcerie, B ;
Gruel, Y ;
Solal-Celigny, P ;
Le Maignan, C ;
Extra, JM ;
Cottu, P ;
Farge, D .
ARCHIVES OF INTERNAL MEDICINE, 2002, 162 (15) :1729-1735
[93]   Anti-cancer properties of low-molecular-weight heparin: Preclinical evidence [J].
Mousa, Shaker A. ;
Petersen, Lars J. .
THROMBOSIS AND HAEMOSTASIS, 2009, 102 (02) :258-267
[94]  
NANNINGA PB, 1990, THROMB HAEMOSTASIS, V64, P361
[95]   Management of venous thromboembolism in patients with advanced cancer: a systematic review and meta-analysis [J].
Noble, Simon I. R. ;
Shelley, Mike D. ;
Coles, Bernadette ;
Williams, Susan M. ;
Wilcock, Andrew ;
Johnson, Miriam J. .
LANCET ONCOLOGY, 2008, 9 (06) :577-584
[96]  
Nurmohamed MT, 1996, THROMB HAEMOSTASIS, V75, P233
[97]   Unsuspected pulmonary emboli adversely impact survival in patients with cancer undergoing routine staging multi-row detector computed tomography scanning [J].
O'Connell, C. ;
Razavi, P. ;
Ghalichi, M. ;
Boyle, S. ;
Vasan, S. ;
Mark, L. ;
Caton, A. ;
Duddalwar, V. ;
Boswell, W. ;
Grabow, K. ;
Liebman, H. A. .
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2011, 9 (02) :305-311
[98]   Venous Thromboembolism in Cancer Patients Undergoing Major Surgery [J].
Osborne, Nicolas H. ;
Wakefield, Thomas W. ;
Henke, Peter K. .
ANNALS OF SURGICAL ONCOLOGY, 2008, 15 (12) :3567-3578
[99]   Symptomatic venous thromboembolism in cancer patients treated with chemotherapy - An underestimated phenomenon [J].
Otten, HMMB ;
Mathijssen, J ;
ten Cate, H ;
Soesan, M ;
Inghels, M ;
Richel, DJ ;
Prins, MH .
ARCHIVES OF INTERNAL MEDICINE, 2004, 164 (02) :190-194
[100]   Biomarkers for prediction of venous thromboembolism in cancer [J].
Pabinger, Ingrid ;
Thaler, Johannes ;
Ay, Cihan .
BLOOD, 2013, 122 (12) :2011-2018