METHOTREXATE, MITOXANTRONE, 5-FLUOROURACIL AND LEUCOVORIN IN METASTATIC BREAST-CANCER PATIENTS

被引：0
作者：
MERLINI, L
SECONDO, V
MAMMOLITI, S
BELLOTTI, P
CASTELLO, C
GALLO, L
机构：
来源：
ANTICANCER RESEARCH | 1994年 / 14卷 / 3B期
关键词：
BIOCHEMICAL MODULATION; SALVAGE TREATMENT; BREAST CANCER;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We have evaluated the efficacy and toxicity of a chemotherapy consisting of methotrexate, mitoxantrone, 5-Fluorouracil and leucovorin in 21 advanced breast cancer patients. Among 20 evaluable patients, objective response was obtained in 6 patients (30%) with two complete responses, stable disease in 4 patients (20%), while 10 patients (50%) progressed. Median progression-free survival and survival were 10 and 15 months, respectively. The most frequently observed side-effects were myelosuppression and emesis; one patient, who had previously received doxorubicin at the maximum dose-limiting cardiac toxicity, died of congestive heart failure after the third cycle. This treatment is moderately effective for advanced breast cancer patients.
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页码：1423 / 1425
页数：3
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