CELLULAR BOUND BETA-CAROTENE QUENCHES SINGLET OXYGEN IN MAN

被引：19

作者：

BOHM, F

HALEY, J

TRUSCOTT, TG

SCHALCH, W

机构：

[1] UNIV BERLIN,HAUTKLIN,CHARITE,SCHUMANNSTR 20-21,W-1040 BERLIN,GERMANY

[2] F HOFFMANN LA ROCHE & CO LTD,DEPT HUMAN NUTR & HLTH,DIV VITAMINS & FINE CHEM,PHARMA IND UNIT,CH-4002 BASEL,SWITZERLAND

[3] UNIV KEELE,DEPT CHEM,KEELE ST5 5BG,STAFFS,ENGLAND

来源：

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY | 1993年 / 21卷 / 2-3期

关键词：

BETA-CAROTENE; SINGLET OXYGEN; CAROTENE-CELL BINDING;

D O I：

10.1016/1011-1344(93)80186-D

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It is often postulated that a major role of carotenoids in biology and medicine involves their ability to quench a toxic form of oxygen, known as singlet oxygen, although direct observations of such mechanisms do not exist. Using beta-carotene, bound to lymphocytes taken from human blood, we have used a direct, pulsed laser, physical chemical technique and, separately, a biological method to show a particularly efficient quenching reaction of singlet oxygen by carotene in a cellular environment.

引用

页码：219 / 221

页数：3

共 7 条

[1] Foote, Denny, Chemistry of singlet oxygen, VII: quenching by β-carotene, J. Am. Chem. Soc., 90, pp. 6233-6235, (1968)
[2] Farmilo, Wilkinson, On the mechanism of quenching of singlet oxygen in solution, Photochem. Photobiol., 18, pp. 447-450, (1973)
[3] Di Mascio, Kaiser, Sies, Lycopene as the most efficient biological carotenoid singlet oxygen quencher, Arch. Biochem. Biophys., 274, pp. 532-538, (1989)
[4] Conn, Schalch, Truscott, The singlet oxygen and carotenoid interactions, J. Photochem. Photobiol. B: Biol., 11, pp. 41-47, (1991)
[5] Bohm, Meffert, Bauer, PUVA therapy damages psoriatic and normal lymphoid cells within milliseconds, Arch. Dermatol. Res., 279, pp. 16-19, (1986)
[6] Keene, Kessel, Land, Redmond, Truscott, Direct detection of singlet oxygen sensitized by haematoporphyrin and related compounds, Photochem. Photobiol., 43, pp. 117-120, (1986)
[7] Baker, Kanofsky, Quenching of singlet oxygen by biomolecules from L1210 leukemia cells, Photochem. Photobiol., 55, pp. 523-528, (1992)

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