PERCUTANEOUS PENETRATION IN-VIVO OF AMINO-ACIDS

An alternative analytical methodology has been developed to evaluate the in vivo percutaneous penetration of non-radioactive compounds in human stratum corneum by the stripping technique. Different amino acids were applied and even though a slight influence of their structure was found on percutaneous penetration, some topical application strategies such as vehicles, skin preparation and evaporation conditions were considered to be important for skin permeation. The amino acid amount found in the stratum corneum could probably be sufficient to express its moisturizing action.