ANALYSIS OF THE EFFECTIVENESS OF THE COMBINED TREATMENT OF PATIENTS WITH LARYNGEAL PAPILLOMATOSIS

Laryngeal papillomatosis is one of the most common tumor diseases of the upper respiratory tract, the morphological substrate of which is papilloma, leading to chronic obstruction of the larynx and hoarseness, occurring in both children and adults. The main etiological factor of laryngeal papillomatosis is the human papillomavirus. There are data that about 10%-60% of the population is affected by latent human papillomavirus infection, as evidenced by the detection of human papillomavirus DNA in the externally unchanged mucosa in 78.5% of the examined. Papillomas make up 3.5% of all benign tumors of the ENT organs and from 20 to 45% of all benign tumors of this localization. Laryngeal papillomatosis is characterized by recurrent course and rapid growth, which requires multiple surgical interventions. In order to eliminate laryngeal stenosis for a long period, tracheotomy remained practically the only method of surgical treatment. Up to now, more than 50 different methods of treatment of laryngeal papillomatosis are known, but a radical etiopathogenetic agent has not been found yet. It should be noted that about 70% of patients have a frequent case of the disease. Therefore, the problem of treatment of respiratory papillomatosis is one of the most urgent in modern otorhinolaryngology and currently largely unsolvable. Medical practice is based on three main directions and their different combinations: the improvement of surgical methods, the search for the new drugs (antiviral, immunotropic, etc.) and the development of vaccination methods. At present, there is no single international standard for the treatment of laryngeal papillomatosis, but it is known that it should be comprehensive. The article presents a study of cold plasma surgery application and the use of a fundamentally new drug in otorhinolaryngology i. e. inductor of interferon synthesis.